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http://acervodigital.unesp.br/handle/11449/133715
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DC Field | Value | Language |
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dc.contributor.author | Martins, Anfrá B. | - |
dc.contributor.author | Ximenes, Valdecir Farias | - |
dc.contributor.author | Fonseca, Luiz Marcos da | - |
dc.date.accessioned | 2016-01-28T16:56:17Z | - |
dc.date.accessioned | 2016-10-25T21:28:43Z | - |
dc.date.available | 2016-01-28T16:56:17Z | - |
dc.date.available | 2016-10-25T21:28:43Z | - |
dc.date.issued | 2013 | - |
dc.identifier | http://dx.doi.org/10.4236/ojcd.2013.31002 | - |
dc.identifier.citation | Open Journal of Clinical Diagnostics, v. 3, n. 1, p. 5-8, 2013. | - |
dc.identifier.issn | 2162-5816 | - |
dc.identifier.uri | http://hdl.handle.net/11449/133715 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/133715 | - |
dc.description.abstract | Raised myeloperoxidase (MPO) serum levels are associated with endothelial dysfunction and cigarette smoking is a risk factor for cardiovascular diseases. Since myocardial infarction is associated with leukocytosis and smokers present increased levels of neutrophils, here we hypothesized that the levels of serum MPO in smokers could be also raised. We carried out a study on sixty eight adult healthy volunteers. The control group consisted of thirty four non-smokers and the test group was thirty four heavy smokers. The hemogram, interleukin-8 (IL-8) and MPO serum levels were measured. Neutrophil, monocyte and lymphocyte counts were higher (p < 0.05) and the serum levels of interleukin-8 (IL-8) and MPO were fourfold higher in smokers than in non-smokers (n = 34, p < 0.05). This result correlated perfectly with the increased neutrophil count and IL-8 serum level that characterize smoking subjects. We propose that the high level of serum MPO could be directly involved in the higher prevalence of coronary artery diseases among heavy smokers. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 5-8 | - |
dc.language.iso | eng | - |
dc.source | Currículo Lattes | - |
dc.subject | Smokers | en |
dc.subject | Neutrophils | en |
dc.subject | IL-8 | en |
dc.subject | Myeloperoxidase | en |
dc.subject | Hypochlorous acid | en |
dc.subject | Atherosclerosis | en |
dc.title | Serum myeloperoxidase level is Increased in heavy smokers | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Araçatuba, SP, Brasil | - |
dc.description.affiliation | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química, Faculdade de Ciências, UNESP/Campus de Bauru, Bauru, Av Eng Luiz Edmundo Carrijo Coube, S/N, Vargem Limpa, CEP 17033360, SP, Brasil | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Araçatuba, SP, Brasil | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química, Faculdade de Ciências, UNESP/Campus de Bauru, Bauru, Av Eng Luiz Edmundo Carrijo Coube, S/N, Vargem Limpa, CEP 17033360, SP, Brasil | - |
dc.identifier.doi | 10.4236/ojcd.2013.31002 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Open Journal of Clinical Diagnostics | - |
dc.identifier.lattes | 4066413997908572 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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