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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/133715
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dc.contributor.authorMartins, Anfrá B.-
dc.contributor.authorXimenes, Valdecir Farias-
dc.contributor.authorFonseca, Luiz Marcos da-
dc.date.accessioned2016-01-28T16:56:17Z-
dc.date.accessioned2016-10-25T21:28:43Z-
dc.date.available2016-01-28T16:56:17Z-
dc.date.available2016-10-25T21:28:43Z-
dc.date.issued2013-
dc.identifierhttp://dx.doi.org/10.4236/ojcd.2013.31002-
dc.identifier.citationOpen Journal of Clinical Diagnostics, v. 3, n. 1, p. 5-8, 2013.-
dc.identifier.issn2162-5816-
dc.identifier.urihttp://hdl.handle.net/11449/133715-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/133715-
dc.description.abstractRaised myeloperoxidase (MPO) serum levels are associated with endothelial dysfunction and cigarette smoking is a risk factor for cardiovascular diseases. Since myocardial infarction is associated with leukocytosis and smokers present increased levels of neutrophils, here we hypothesized that the levels of serum MPO in smokers could be also raised. We carried out a study on sixty eight adult healthy volunteers. The control group consisted of thirty four non-smokers and the test group was thirty four heavy smokers. The hemogram, interleukin-8 (IL-8) and MPO serum levels were measured. Neutrophil, monocyte and lymphocyte counts were higher (p < 0.05) and the serum levels of interleukin-8 (IL-8) and MPO were fourfold higher in smokers than in non-smokers (n = 34, p < 0.05). This result correlated perfectly with the increased neutrophil count and IL-8 serum level that characterize smoking subjects. We propose that the high level of serum MPO could be directly involved in the higher prevalence of coronary artery diseases among heavy smokers.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent5-8-
dc.language.isoeng-
dc.sourceCurrículo Lattes-
dc.subjectSmokersen
dc.subjectNeutrophilsen
dc.subjectIL-8en
dc.subjectMyeloperoxidaseen
dc.subjectHypochlorous aciden
dc.subjectAtherosclerosisen
dc.titleSerum myeloperoxidase level is Increased in heavy smokersen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Araçatuba, SP, Brasil-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química, Faculdade de Ciências, UNESP/Campus de Bauru, Bauru, Av Eng Luiz Edmundo Carrijo Coube, S/N, Vargem Limpa, CEP 17033360, SP, Brasil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Análises Clínicas, Faculdade de Ciências Farmacêuticas, Araçatuba, SP, Brasil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Química, Faculdade de Ciências, UNESP/Campus de Bauru, Bauru, Av Eng Luiz Edmundo Carrijo Coube, S/N, Vargem Limpa, CEP 17033360, SP, Brasil-
dc.identifier.doi10.4236/ojcd.2013.31002-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofOpen Journal of Clinical Diagnostics-
dc.identifier.lattes4066413997908572-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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