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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/133758
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dc.contributor.authorYoshida, Valquíria M. H.-
dc.contributor.authorGranato, Elis-
dc.contributor.authorGremião, Maria Palmira Daflon-
dc.contributor.authorBalcão, Victor M.-
dc.contributor.authorVila, M. M. D. C.-
dc.contributor.authorOliveira Júnior, José M.-
dc.contributor.authorSeverino, Patrícia-
dc.contributor.authorSouto, Eliana B-
dc.contributor.authorChaus, Marco Vinícius-
dc.date.accessioned2016-01-28T16:56:30Z-
dc.date.accessioned2016-10-25T21:28:49Z-
dc.date.available2016-01-28T16:56:30Z-
dc.date.available2016-10-25T21:28:49Z-
dc.date.issued2013-
dc.identifierhttp://academicjournals.org/journal/AJPP/article-abstract/525104242454-
dc.identifier.citationAfrican Journal of Pharmacy and Pharmacology, v. 7, n. 46, p. 2946-3946, 2013.-
dc.identifier.issn1996-0816-
dc.identifier.urihttp://hdl.handle.net/11449/133758-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/133758-
dc.description.abstractThe aim of the research effort entertained herein was to develop, evaluate and fully characterize a multiparticulate floating gastroretentive system for the modified release of zidovudine (AZT), an antiretroviral drug. AZT was used as a water-soluble model drug at therapeutic doses. The floating gastroretentive system was obtained via polymer coating of calcium silicate-adsorbed AZT. The proposed system was evaluated in vitro for particle micromorphology, lag time for floating and duration of floating, drug loading capacity, drug release profile, and drug release kinetics. The physicochemical properties of AZT were evaluated by scanning electron microscopy (SEM) analyses, differential scanning calorimetry (DSC) analyses, X-ray diffraction (XRD) analyses, and infrared spectroscopy (FTIR) analyses. Results from SEM analysis of the AZT-containing floating gastroretentive granules allowed observation of an irregular surface and the apparent absence of pores. Floating of the AZT-containing gastroretentive granules was immediately achieved, that is lag time for floating was virtually zero and duration of floating was higher than 12 h. The drug loading capacity of the floating gastroretentive granules was ca. 81.09 ± 14.66%, and the release system thus obtained exhibited an extended drug release profile. Results from DSC and XRD analyses showed a modification in the AZT solid state, while the FTIR spectroscopy analyses revealed that the chemical structure of AZT remained unchanged upon adsorption to calcium silicate followed by polymeric coating. Hence, the coated granules produced presented gastroretentive, floating, and extended drug release properties.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipFundação Portuguesa de Ciência e Tecnologia-
dc.format.extent2946-3946-
dc.language.isoeng-
dc.publisherAcademic Journals-
dc.sourceCurrículo Lattes-
dc.subjectZidovudineen
dc.subjectCal-sil floating granulesen
dc.subjectGastroretentive floating systemen
dc.subjectExtended drug releaseen
dc.subjectZidovudine (AZT)en
dc.subjectPolymer coatingen
dc.titleA novel gastroretentive floating system for zidovudine, based on calcium-silicate beadsen
dc.typeoutro-
dc.contributor.institutionUniversidade de Sorocaba (UNISO)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade de Trás-os-Montes e Alto Douro (UTAD)-
dc.contributor.institutionUniversidade Fernando Pessoa-
dc.contributor.institutionUniversidade do Minho (UM)-
dc.description.affiliationLaboratory for the Development and Evaluation of Bioactive Substance, Sorocaba University - UNISO, Sorocaba, SP, Brazil-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Farmacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara - Jaú km 1, CEP 14801-902, SP, Brasil-
dc.description.affiliationDepartment of Biotechnological Process, School of Enginnering Chemical, University of Campinas – UNICAMP, Campinas, Brazil-
dc.description.affiliationInstitute of Biotechnology and Bioengineering, Centre of Genetics and Biotechnology, University of Trás-os-Montes and Alto Douro (IBB/CGB-UTAD), Vila Real, Portugal-
dc.description.affiliationFaculty of Health Sciences, Fernando Pessoa University, Rua Carlos da Maia, 296, P-4200-150 Porto, Portugal-
dc.description.affiliationInstitute for Biotechnology and Bioengineering (IBB), Centre for Biological Engineering, University of Minho, Campus de Gualtar, P-4710-057 Braga, Portugal-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Farmacos e Médicamentos, Faculdade de Ciências Farmacêuticas de Araraquara, Araraquara, Rodovia Araraquara - Jaú km 1, CEP 14801-902, SP, Brasil-
dc.description.sponsorshipIdFAPESP: 2011/51077-8-
dc.description.sponsorshipIdFundação Portuguesa de Ciência e Tecnologia: PTDC/SAU-FAR/113100/2009-
dc.identifier.doi10.5897/AJPP2013.3808-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileISSN1996-0816-2013-07-2946-3946.pdf-
dc.relation.ispartofAfrican Journal of Pharmacy and Pharmacology-
dc.identifier.lattes9129780536724256-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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