You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/13503
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMeira, Domingos Alves-
dc.contributor.authorPellegrino Júnior, Jordão-
dc.contributor.authorMarcondes-Machado, Jussara-
dc.contributor.authorTsuji, Kimiyoski-
dc.contributor.authorMatsuoka, Elinda Satie-
dc.contributor.authorHaida, Elizete-
dc.contributor.authorKhoury, Albert Boutros El-
dc.date.accessioned2014-05-20T13:38:56Z-
dc.date.available2014-05-20T13:38:56Z-
dc.date.issued1987-09-01-
dc.identifierhttp://dx.doi.org/10.1590/S0037-86821987000300005-
dc.identifier.citationRevista da Sociedade Brasileira de Medicina Tropical. Sociedade Brasileira de Medicina Tropical - SBMT, v. 20, n. 3, p. 153-158, 1987.-
dc.identifier.issn0037-8682-
dc.identifier.urihttp://hdl.handle.net/11449/13503-
dc.description.abstractEm agosto de 1983 foram observados 85 habitantes do Município de Humaitá, Estado do Amazonas, Brasil, com a finalidade de estudar a prevalência dos antígenos de HLA -A, -B, -C e DR, dentre os quais 38 eram doentes com malária causada pelo Plasmodium falciparum Todos eles foram examinados para avaliação de esplenomegalia, exame parasitológico de sangue e pesquisa de anticorpos de malária. Foram constituídos três grupos: (I) 25 indivíduos nascidos na região Amazônica que nunca tiveram malária; (II) 38 indivíduos naturais da Amazônia que tinham sido tratados de malária no passado, ou que estavam tendo malária atual, e (III) 22 doentes com malária que contraíram na Amazônia e eram procedentes de outras regiões do Brasil. Foram colhidas amostras de sangue de cada um deles, separados os linfôcitos e os antígenos de HLA foram tipados pelo teste de microlinfocitotoxidade. Houve elevada freqüência de antígenos não identificados, nos grupos estudados, o que sugere ou a existência de homozigoze, oufenôtipo não identificado nessa população. Houve alta freqüência fenotípica de antígeno deAg(W24) (44,7%) no Grupo II, quando comparado ao Grupo 1(32%) ou Grupo III (9%). Os indivíduos do Grupo II mostraram também elevada freqüência do antígeno DR4 (80%) quando comparado ao Grupo 1(36,3%) ou Grupo III(16,6%). Essas observações sugerem a possibilidade de suscetibilidadegenética ã malária entre os nativos da Amazônia e indicam a necessidade da realização de inquéritos mais extensos sobre a freqüência de antígenos de HLA em habitantes de zona endêmica de malária.pt
dc.description.abstractIn August 1983,85 inhabitants of the municipality of Humaitá, Amazonas State, Brazil were studied to determine the prevalence of antigens to HLA-A, -B, -C and DR. Thirty-eight were sick with malaria due to Plasmodium falciparum. All subjects were examined for splenomegaly, blood parasitaemia and antibodies to malaria. They constituted three groups: 1) 25 subjects native to the Amazon region who had never had malaria; 2) 38 Amazonian subjects who had malaria in the past or currently had an infection; 3) 22 patients with malaria who had acquired the infection in the Amazon Region but came from other regions of Brazil. Blood was taken from each person, the lymphocytes were separated and typed by the test of microlymphocytotoxicity. There was a high frequency of antigens that could not be identified in the groups studied which suggests the existence of a homozygote or phenotype not identified in the population. There was a high frequency of the phenotype Ag(W24) (44.7%) in group 2 when compared with group 1 (32%) or group 3 (9%). Also the individuals in group 2 showed an elevated frequency of antigen DR(4)80%) when compared with group 1 (36.6%) or group 3 (16.6%). These observations suggest the possibility of a genetic susceptibility to malaria among Amazonian residents and indicate a necessity for more extensive studies of the frequency of HLA antigens among inhabitants of this endemic malarial zone.en
dc.format.extent153-158-
dc.language.isoeng-
dc.publisherSociedade Brasileira de Medicina Tropical - SBMT-
dc.sourceSciELO-
dc.subjectMaláriapt
dc.subjectPlasmodium falciparumpt
dc.subjectPrevalência de HLApt
dc.subjectPlasmodium falciparum malariaen
dc.subjectHLA frequencyen
dc.titleFrequency of human leukocyte antigen (hla) in patients with malaria and in the general population of Humaitá county, Amazonas state, Brazilen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionTokai University School of Medicine Transplantation Immunology Center-
dc.contributor.institutionHospital do Servidor Público do Estado de São Paulo-
dc.description.affiliationUNESP School of Medicine Department of Infectious and Parasitic Diseases-
dc.description.affiliationUNESP School of Medicine Department of Urology-
dc.description.affiliationTokai University School of Medicine Transplantation Immunology Center-
dc.description.affiliationHospital do Servidor Público do Estado de São Paulo-
dc.description.affiliationUnespUNESP School of Medicine Department of Infectious and Parasitic Diseases-
dc.description.affiliationUnespUNESP School of Medicine Department of Urology-
dc.identifier.doi10.1590/S0037-86821987000300005-
dc.identifier.scieloS0037-86821987000300005-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0037-86821987000300005.pdf-
dc.relation.ispartofRevista da Sociedade Brasileira de Medicina Tropical-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.