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http://acervodigital.unesp.br/handle/11449/13589
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DC Field | Value | Language |
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dc.contributor.author | Credie, Renato G. | - |
dc.contributor.author | Teixeira Neto, Francisco José | - |
dc.contributor.author | Ferreira, Tatiana H. | - |
dc.contributor.author | Aguiar, Antonio J. A. | - |
dc.contributor.author | Restitutti, Fabio C. | - |
dc.contributor.author | Corrente, Jose E. | - |
dc.date.accessioned | 2014-05-20T13:39:12Z | - |
dc.date.accessioned | 2016-10-25T16:55:05Z | - |
dc.date.available | 2014-05-20T13:39:12Z | - |
dc.date.available | 2016-10-25T16:55:05Z | - |
dc.date.issued | 2010-05-01 | - |
dc.identifier | http://dx.doi.org/10.1111/j.1467-2995.2010.00528.x | - |
dc.identifier.citation | Veterinary Anaesthesia and Analgesia. Malden: Wiley-blackwell, v. 37, n. 3, p. 240-249, 2010. | - |
dc.identifier.issn | 1467-2987 | - |
dc.identifier.uri | http://hdl.handle.net/11449/13589 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/13589 | - |
dc.description.abstract | Objective To investigate the effects of methadone on the minimum alveolar concentration of isoflurane (ISO(MAC)) in dogs.Study design Prospective, randomized cross-over experimental study.Animals Six adult mongrel dogs, four males and two females, weighing 22.8 +/- 6.6 kg.Methods Animals were anesthetized with isoflurane and mechanically ventilated on three separate days, at least 1 week apart. Core temperature was maintained between 37.5 and 38.5 degrees C during ISO(MAC) determinations. on each study day, ISO(MAC) was determined using electrical stimulation of the antebrachium (50 V, 50 Hz, 10 mseconds) at 2.5 and 5 hours after intravenous injection of physiological saline (control) or one of two doses of methadone (0.5 or 1.0 mg kg(-1)).Results Mean (+/- SD) ISO(MAC) in the control treatment was 1.19 +/- 0.15% and 1.18 +/- 0.15% at 2.5 and 5 hours, respectively. The 1.0 mg kg(-1) dose of methadone reduced ISO(MAC) by 48% (2.5 hours) and by 30% (5 hours), whereas the 0.5 mg kg(-1) dose caused smaller reductions in ISO(MAC) (35% and 15% reductions at 2.5 and 5 hours, respectively). Both doses of methadone decreased heart rate (HR), but the 1.0 mg kg(-1) dose was associated with greater negative chronotropic actions (HR 37% lower than control) and mild metabolic acidosis at 2.5 hours. Mean arterial pressure increased in the MET1.0 treatment (13% higher than control) at 2.5 hours.Conclusions and clinical relevance Methadone reduces ISO(MAC) in a dose-related fashion and this effect is lessened over time. Although the isoflurane sparing effect of the 0.5 mg kg(-1) dose of methadone was smaller in comparison to the 1.0 mg kg(-1) dose, the lower dose is recommended for clinical use because it results in less evidence of cardiovascular impairment. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 240-249 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.source | Web of Science | - |
dc.subject | isoflurane | en |
dc.subject | methadone | en |
dc.subject | minimum alveolar concentration | en |
dc.title | Effects of methadone on the minimum alveolar concentration of isoflurane in dogs | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Helsinki | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Med Vet & Zootecnia, Dept Cirurgia & Anestesiol Vet, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliation | Univ Helsinki, Fac Vet Med, Dept Vet Clin Sci, Helsinki, Finland | - |
dc.description.affiliation | Univ Estadual Paulista, Inst Biociencias, Dept Bioestatist, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Departamento de Cirurgia e Anestesiologia Veterinária, Faculdade de Medicina Veterinária e Zootecnia, Universidade Estadual Paulista, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Departmento de Bioestatística, Instituto de Biociências, Universidade Estadual Paulista, Botucatu, SP, Brazil | - |
dc.identifier.doi | 10.1111/j.1467-2995.2010.00528.x | - |
dc.identifier.wos | WOS:000276409300007 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Veterinary Anaesthesia and Analgesia | - |
dc.identifier.orcid | 0000-0001-5478-4996 | pt |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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