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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/13611
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dc.contributor.authorGarofalo, Natache A.-
dc.contributor.authorTeixeira Neto, Francisco José-
dc.contributor.authorSchwartz, Denise S.-
dc.contributor.authorVailati, Maria do Carmo F.-
dc.contributor.authorSteagall, Paulo V. M.-
dc.date.accessioned2014-05-20T13:39:15Z-
dc.date.accessioned2016-10-25T16:55:07Z-
dc.date.available2014-05-20T13:39:15Z-
dc.date.available2016-10-25T16:55:07Z-
dc.date.issued2008-07-01-
dc.identifierhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC2442680/-
dc.identifier.citationCanadian Journal of Veterinary Research-revue Canadienne de Recherche Veterinaire. Ottawa: Canadian Vet Med Assoc, v. 72, n. 4, p. 362-366, 2008.-
dc.identifier.issn0830-9000-
dc.identifier.urihttp://hdl.handle.net/11449/13611-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/13611-
dc.description.abstractOpioids may exert a protective effect against ventricular arrhythmias via a vagally mediated mechanism. This study evaluated the effects of the opioid remifentanil on arrhythmogenicity of epinephrine during halothane anesthesia. Eight dogs were assigned to 2 treatments in a randomized crossover design, with 1-week intervals between treatments. Anesthesia was maintained with 1.3% end-tidal halothane in oxygen and mechanical ventilation to maintain eucapnia. A constant rate infusion of remifentanil (0.72 mu g/kg/min) was administered throughout the study in the experimental treatment, while control animals received physiologic saline as placebo. The arrhythmogenic dose of epinephrine (ADE), defined as 4 premature ventricular complexes (PVCs) within 15 s, was determined by administering progressively increasing infusion rates of epinephrine (2.5, 5.0, and 10 mu g/kg/min), allowing 20 min intervals between each infusion rate. In both treatments, epinephrine infusions induced bradyarrhythmias and atrioventricular conduction disturbances, which were followed by escape beats and PVCs. In the remifentanil treatment, mean s ADE values (11.3 +/- 4.9 mu g/kg) did not differ from values observed in control animals (9.9 +/- 6.1 mu g/kg). on the basis of the ADE model for assessing the arrhythmogenity of drugs during halothane anesthesia, the present study did not demonstrate a protective effect of remifentanil (0.72 mu g/kg/min) against ventricular arrhythmias in dogs.en
dc.format.extent362-366-
dc.language.isoeng-
dc.publisherCanadian Vet Med Assoc-
dc.sourceWeb of Science-
dc.titleEffects of the opiold remifentanil on the arrhythmogenicity of epinephrine in halothane-anesthetized dogsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista, Fac Med Vet & Zootecn, Dept Vet Surg & Anesthesiol, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Med Vet & Zootecn, Dept Vet Clin Sci, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Vet & Zootecn, Dept Vet Surg & Anesthesiol, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Med Vet & Zootecn, Dept Vet Clin Sci, BR-18618000 Botucatu, SP, Brazil-
dc.identifier.wosWOS:000257974000010-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofCanadian Journal of Veterinary Research = Revue Canadienne de Recherche Veterinaire-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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