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dc.contributor.authorSolano, Marize de Lourdes Marzo-
dc.contributor.authorRaimundo, Cassiana Carolina Montagner-
dc.contributor.authorVaccari, Carolina-
dc.contributor.authorJardim, Wilson F.-
dc.contributor.authorFranci, Janete Aparecida Anselmo-
dc.contributor.authorCarolino, Ruither de O G-
dc.contributor.authorLuvizutto, João Francisco Lozano-
dc.contributor.authorUmbuzeiro, Gisela Aragão-
dc.contributor.authorCamargo, João Lauro Viana de-
dc.identifier.citationEndocrine Disruptors, v. 3, n. 1, p. e983384, 2015.-
dc.description.abstractConventional water treatment plants (WTP) do not completely remove contaminants with endocrine activity which may then be present in drinking water (DW). The potential for endocrine disruption of 2 DW samples collected in 2010 and 2012 from a conventional WTP in São Paulo, Brazil was investigated. In vivo assays were conducted with 21-day old female rats exposed to DW extracts for 3- (uterotrophic assay) or 20-days (pubertal assay). The exposure represented a daily ingestion of 2 L, 10 L and 20 L of DW per 60 kg-body weight. Caffeine (5.8 – 21 ug/L), estrone (1 ng/L), atrazine (2.2 – 11.2 ng/L), carbendazim (0.22 ng/L), azoxystrobin (0.23 ng/L), tebuconazole (0.19 ng/L) and imidacloprid (0.88 ng/L) were detected in DW extracts by LC-MS/MS. No increase in uterus wet weight in the uterotrophic assay, and no alteration of vaginal opening in the pubertal assay were observed. However, there were increased absolute blotted uterus weights in animals treated for 3-days with the 3 doses of both DW samples. LH and FSH levels showed significant dose-response increases in the uterotrophic assay using the 2010 DW sample, in association with a significantly increased incidence of vaginal keratinization after the 3-day exposure. The pubertal animals exposed to the 2010 DW had a significant body weight gain and decreased LH at the highest dose. Results suggest that DW samples tested exerted estrogenic and hypothalamic-hypophysis activity alterations in vivo.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.sourceCurrículo Lattes-
dc.subjectEmerging contaminantsen
dc.subjectEndocrine disruptionen
dc.subjectPubertal female rat developmenten
dc.subjectUterotrophic assayen
dc.titlePotential endocrinedisruptor activity of drinking water samplesen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Patologia, Faculdade de Medicina de Botucatu, Botucatu, Distrito de Rubião Jr., CEP 18610-000, SP, Brasil-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Patologia, Faculdade de Medicina de Botucatu, Botucatu, Distrito de Rubião Jr., CEP 18610-000, SP, Brasil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEndocrine Disruptors-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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