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dc.contributor.authorGoldberg, Tamara Beres Lederer-
dc.contributor.authorFortes, Cristina Maria Teixeira-
dc.contributor.authorKurokawa, Cilmery Suemi-
dc.contributor.authorSilva, Carla Cristiane-
dc.contributor.authorMoretto, Maria Regina-
dc.contributor.authorNunes, Helio R. D. C.-
dc.identifier.citationArchies Of Disease In Childhood, v. 97, p. A126, 2012.-
dc.description.abstractBackground and Aims Bone metabolism involves understanding many factors, especially during puberty, when bone turnover is significant and the bone mass peak must be achieved as a protective factor of future bone health. The objective was to evaluate the behavior of formation and resorption bone biomarkers (BB) in function of biological maturation in female adolescents.Methods Evaluation of formation and resorption BB, osteocalcin (OC), bone alkaline phosphatase (BAP) and carboxyterminal telopeptide (S-CTx) by correlating them with bone mineralization, bone age and pubertal development in healthy female adolescents. Seventy-two volunteers were subdivided into groups according to chronological age/bone age (BA): 10 11 years (n=12), 12 13 years (n=16), 14 15 years (n=15) and 16 19 years (n=29). The following were evaluated: weight (kg), height (m), BMI (kg/m2), calcium intake (3-day 24h food recalls (mg/day), puberty events (Tanner stages), serum OC (ng/mL), BAP (U/L), S-CTx (ng/mL) and bone mineral density (BMD) as calculated by DXA (g/cm2) in the spine (L1-L4), proximal femur and whole body. The project was approved by the UNESP Ethics Committee.Results BB showed similar behaviors, with higher mean values for 10 12 years and when adolescents were in the B2-B3 Pubertal Maturation Stage (B2: BAP=110.16 U/L, OC=33.81ng/mL, S-CTx=1.66 ng/mL and B3: BAP=136.50 U/L, OC=39.15ng/mL and S-CTx=1.88 ng/mL; p<0.001). Mean BB values decreased with advancing BA and pubertal maturity.Conclusions BB values showed parallelism with peak height velocity and significant negative correlation with BMD in the different evaluated sites, with chronological and BA ; higher BMD values correlated with lower bone biomarker values.en
dc.sourceCurrículo Lattes-
dc.titleRelationship between bone ageand pubertal breast stage to bone biomarkers and bone mineral density in healthy brazilian female adolescentspt
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade do Norte do Paraná (UNOPAR)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Pediatria, Faculdade de Medicina de Botucatu, Botucatu, Rubião Júnior, s/nº / Faculdade de Medicina/Depto de Pediatria, Rubião Júnior, CEP 18618970, SP, Brasil-
dc.description.affiliationDepartment of Physical Education, University of North Paraná, Jacarezinho-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Faculdade de Medicina de Botucatu, Botucatu, Rubião Júnior, s/nº / Faculdade de Medicina/Depto de Pediatria, Rubião Júnior, CEP 18618970, SP, Brasil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArchies Of Disease In Childhood-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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