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dc.contributor.authorRosário, Millor Fernandes do-
dc.contributor.authorMargarido, Gabriel Rodrigues Alves-
dc.contributor.authorBoschiero, Clarissa-
dc.contributor.authorMoura, Ana Silvia Alves Meira Tavares-
dc.contributor.authorLedur, Mônica Corrêa-
dc.contributor.authorCoutinho, Luiz Lehmann-
dc.contributor.authorGarcia, Antonio Augusto Franco-
dc.identifier.citationGenetics and Molecular Research, v. 9, n. 3, p. 1357-1376, 2010.-
dc.description.abstractSome factors complicate comparisons between linkage maps from different studies. This problem can be resolved if measures of precision, such as confidence intervals and frequency distributions, are associated with markers. We examined the precision of distances and ordering of microsatellite markers in the consensus linkage maps of chromosomes 1, 3 and 4 from two F2 reciprocal Brazilian chicken populations, using bootstrap sampling. Single and consensus maps were constructed. The consensus map was compared with the International Consensus Linkage Map and with the whole genome sequence. Some loci showed segregation distortion and missing data, but this did not affect the analyses negatively. Several inversions and position shifts were detected, based on 95% confidence intervals and frequency distributions of loci. Some discrepancies in distances between loci and in ordering were due to chance, whereas others could be attributed to other effects, including reciprocal crosses, sampling error of the founder animals from the two populations, F2 population structure, number of and distance between microsatellite markers, number of informative meioses, loci segregation patterns, and sex. In the Brazilian consensus GGA1, locus LEI1038 was in a position closer to the true genome sequence than in the International Consensus Map, whereas for GGA3 and GGA4, no such differences were found. Extending these analyses to the remaining chromosomes should facilitate comparisons and the integration of several available genetic maps, allowing meta-analyses for map construction and quantitative trait loci (QTL) mapping. The precision of the estimates of QTL positions and their effects would be increased with such information.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.sourceCurrículo Lattes-
dc.subjectConfidence intervalen
dc.subjectGallus gallus domesticusen
dc.titlePrecision of distances and ordering of microsatellite markers in consensus linkage maps of chromosomes 1, 3 and 4 from two reciprocal chicken populations using bootstrap samplingen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionEmpresa Brasileira de Pesquisa Agropecuária (EMBRAPA)-
dc.description.affiliationUniversidade de São Paulo, Departamento de Genética, Escola Superior de Agricultura Luiz de Queiroz-
dc.description.affiliationUniversidade de São Paulo, Departamento de Zootecnia, Escola Superior de Agricultura Luiz de Queiroz-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Produção Animal, Faculdade de Medicina Veterinária e Zootecnia de Botucatu-
dc.description.sponsorshipIdFAPESP: 04/02080-2-
dc.description.sponsorshipIdCNPq: 152500-2007/3-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofGenetics and Molecular Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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