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dc.contributor.authorFerreira, Anderson Luiz-
dc.contributor.authorCola, Maíra-
dc.contributor.authorBarbastefano, Vitor-
dc.contributor.authorHiruma-Lima, Clélia Akiko-
dc.contributor.authorSantos, Lourdes Campaner dos-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorBrito, Alba Regina Monteiro Souza-
dc.identifier.citationJournal of Medicinal Plant Research, v. 6, n. 40, p. 5337-5343, 2012.-
dc.description.abstractAnacardium humile St. Hil. is being used in traditional medicine to treat ulcer. The present work evaluated the mechanisms of action involved in the anti-ulcer properties of the aqueous fraction from leaves of A. humile (AHQ). Gastroprotection of A. humile was evaluated in ethanol and piroxicam models. Mechanisms of action such as mucus production, nitric oxide (NO), sulfhydryl compounds (SH) and the anti-secretory action were evaluated. The acetic acid-induced gastric ulcer model was used to evaluate the A. humile healing properties. Results obtained in the ethanol model showed that AHQ provided significant gastroprotection at all the tested doses (50, 100, and 200 mg/kg). Thereby, the following protocols were performed using the dose capable of producing the most effective gastroprotection, which was the AHQ 200 mg/kg (P < 0.001). Moreover, AHQ (200 mg/kg) protected the mucosa from piroxicam-induced damage. Mucus, NO, and SH did not participate on this gastroprotection. AHQ interfere in H+ secretion in gastric mucosa, thus exerting an anti-secretory activity. Our results suggest that the gastroprotection and cicatrisation process executed by AHQ occurred due to its anti-secretory activity. This study reinforces its traditional medicinal use. Considering that the current therapies are based on the use of anti-secretory agents, the A. humile arises as a promising alternative antiulcer therapy.en
dc.sourceCurrículo Lattes-
dc.subjectAnacardium humile St. Hil.en
dc.subjectGastric ulceren
dc.titleAntiulcerogenic activity of the aqueous fraction of Anacardium humile St. Hil (Anacardiaceae)en
dc.contributor.institutionUniversidade Federal de Goiás (UFG)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Federal de Santa Catarina (UFSC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Federal de Goiás, Departamento de Ciências Biológicas-
dc.description.affiliationUniversidade Estadual de Campinas, Departamento de Biologia Estrutural e Funcional, Instituto de Biologia-
dc.description.affiliationUniversidade Federal de Santa Catarina, Departamento de Farmacologia, Instituto de Biologia-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Fisiologia, Instituto de Biociências de Botucatu-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Química Orgânica, Instituto de Química de Araraquara-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Medicinal Plant Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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