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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/140835
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dc.contributor.authorOmoko, Ana Carolina Mieko-
dc.contributor.authorFernandez, Geysson-
dc.contributor.authorMoraes, Leonardo Nazario-
dc.contributor.authorRoscani, Meliza Goi-
dc.contributor.authorCarvalho, Robson Francisco-
dc.contributor.authorGobbi, Juliana Irani Fratucci de-
dc.date.accessioned2016-07-07T12:35:38Z-
dc.date.accessioned2016-10-25T21:44:40Z-
dc.date.available2016-07-07T12:35:38Z-
dc.date.available2016-10-25T21:44:40Z-
dc.date.issued2015-
dc.identifierhttp://www.fasebj.org/content/29/1_Supplement/799.6-
dc.identifier.citationThe FASEB Journal, v. 29, p. 799.6, 2015.-
dc.identifier.issn1530-6860-
dc.identifier.urihttp://hdl.handle.net/11449/140835-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/140835-
dc.description.abstractAortic regurgitation (AR), a volume overload to the heart, impairs systolic function. Paroxetine (parox) treatment, a selective serotonin reuptake inhibitor, improves systolic function in AR rats, probably due decreases in the expression of β-myosin heavy chain (βMyHC) gene. An intricate network regulate genes co-expressing microRNAs (miR-208a,-208b and -499) and transcriptional repressors which in turn controls MyHCisoforms content. Thus, we verify the gene expression of those microRNAs and the transcriptional repressor (Thrap1) in AR rats treated with parox. Male Wistar rats (280-300kg) were submitted to sham or AR surgery. Morphofunctional variables of the hearts were analyzed by echocardiograms. Parox (10mg/kg) was administered subcutaneously for 4 weeks. There were 4 groups: AR+parox, AR+saline, Sham+parox and Sham+saline. At week 8 the animals were euthanized for tissue collection and analysis of gene expression by RTq-PCR. Two way repeated measures ANOVA were used for comparisons. Parox treatment preserved the fractional shortening in AR rats. The expression of miR-208a and Thrap 1 were not changed. Though there was a decrease in miR-208b and miR-499 gene expression, which may regulate the decrease of β-MyHC isoform in AR rats treated with parox, explaining the improvement in systolic function.en
dc.description.sponsorshipFundação de Amparo a Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent7996-
dc.language.isoeng-
dc.sourceCurrículo Lattes-
dc.titleImprovement in fractional shortening in aortic regurgitation rats: cardiac muscle networken
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCAR)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia, Instituto de Biociências (IBB), Botucatu-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Morfologia, Instituto de Biociências (IBB), Botucatu-
dc.description.affiliationUniversidade Federal de São Carlos (UFSCAR)-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia, Instituto de Biociências (IBB), Botucatu-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Morfologia, Instituto de Biociências (IBB), Botucatu-
dc.description.sponsorshipIdFAPESP: 2013/11372-6-
dc.description.sponsorshipIdFAPESP: 2013/00742-7-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofThe FASEB Journal-
dc.identifier.orcid0000-0002-4901-7714pt
dc.identifier.lattes1298051150234140-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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