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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/141044
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dc.contributor.authorSouza, Juliane Coelho de-
dc.contributor.authorPiccinelli, Ana Claudia-
dc.contributor.authorAquino, Diana Figueiredo-
dc.contributor.authorSouza, Vanessa Vilamaior de-
dc.contributor.authorSchmitz, Wanderlei Onofre-
dc.contributor.authorTraesel, Giseli Karenina-
dc.contributor.authorCardoso, Claudia Andrea de Lima-
dc.contributor.authorKassuya, Candida Aparecida Leite-
dc.contributor.authorArena, Arielle Cristina-
dc.date.accessioned2016-07-07T12:36:35Z-
dc.date.accessioned2016-10-25T21:45:12Z-
dc.date.available2016-07-07T12:36:35Z-
dc.date.available2016-10-25T21:45:12Z-
dc.date.issued2014-
dc.identifierhttp://dx.doi.org/10.1179/1476830514y.0000000145-
dc.identifier.citationNutritional Neuroscience, 2016.-
dc.identifier.issn1028-415X-
dc.identifier.urihttp://hdl.handle.net/11449/141044-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/141044-
dc.description.abstractObjective: This study evaluates the anti-inflammatory, antihyperalgesic, and antidepressive potential of the hydroalcoholic extract of Campomanesia adamantium fruit barks (CAE) on rodents and determines the safety of this plant. Methods: The acute toxicity of CAE was evaluated by oral administration to female rats as single doses of 0, 500, 1000, or 2000 mg/kg body weight. General behavior and toxic symptoms were observed for 14 days. In the subacute toxicity test, male and female rats received 125 or 250 mg/kg body weight of CAE for 28 days. The oral anti-inflammatory activity of CAE was evaluated in carrageenan-induced pleurisy in male mice. The effect of treatment with CAE (100 mg/kg) for 15 days was evaluated in mechanical hyperalgesia (electronic von Frey), depressive behavior (forced swimming test), and cold hypersensitivity in spared nerve injury (SNI) model in rats. Results: No clinical signs of toxicity were observed in animals from the experimental groups during acute and subacute exposure to CAE. At pleurisy test, the oral administration of CAE significantly inhibited leukocyte migration and protein leakage at all doses tested when compared to control. Oral administration of CAE for 3–15 days significantly inhibited SNI-induced mechanical hyperalgesia and increased immobility in the forced swim test. Finally, on the 15th day, oral treatment with CAE prevented the increase in sensitivity to a cold stimulus induced by SNI. Discussion: The present study shows that C. adamantium extract has anti-inflammatory, antihyperalgesic, and antidepressive properties in rodents without causing toxicity.en
dc.language.isoeng-
dc.sourceCurrículo Lattes-
dc.subjectCampomanesia adamantium fruit barken
dc.subjectInflammationen
dc.subjectToxicityen
dc.subjectHyperalgesiaen
dc.subjectDepressionen
dc.titleToxicological analysis and antihyperalgesic, antidepressant, and anti-inflammatory effects of Campomanesia adamantium fruit barksen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal da Grande Dourados (UFGD)-
dc.contributor.institutionUniversidade Federal de Mato Grosso do Sul (UFMS)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Morfologia, Instituto de Biociências de Botucatu-
dc.identifier.doi10.1179/1476830514y.0000000145-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofNutritional Neuroscience-
dc.identifier.lattes1950630264589756-
dc.identifier.lattes9778310472010726-
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