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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/141084
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dc.contributor.authorFigueroa, Fernanda Carmelo-
dc.contributor.authorSalgado, Breno Souza-
dc.contributor.authorMonteiro, Lidianne Narducci-
dc.contributor.authorRocha, Rafael Malagoli-
dc.contributor.authorDomingues, Maria Aparecida Custódio-
dc.contributor.authorMartins, Diana-
dc.contributor.authorSchmitt, Fernando-
dc.contributor.authorRocha, Noeme Sousa-
dc.date.accessioned2016-07-07T12:36:46Z-
dc.date.accessioned2016-10-25T21:45:18Z-
dc.date.available2016-07-07T12:36:46Z-
dc.date.available2016-10-25T21:45:18Z-
dc.date.issued2012-
dc.identifierhttp://dx.doi.org/10.4236/ojvm.2012.24026-
dc.identifier.citationOpen Journal of Veterinary Medicine, v. 2, n. 4, p. 163-169, 2012.-
dc.identifier.issn2218-6050-
dc.identifier.urihttp://hdl.handle.net/11449/141084-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/141084-
dc.description.abstractCathepsin D (CD), a lysosomal protease, and S100A4 protein, a calcium binding motif, are considered to be involved in metastasis in various human cancers. No data regarding such proteins are available for canine mammary carcinomas (CMCs). Accordingly, their expression in association with known factors of prognosis was investigated in this study. For that, 66 surgically resected CMCs were submitted to an immunohistochemical evaluation using anti CD, S100A4 protein, HER2, estrogen receptor α, cytokeratin 5, and p63 antibodies, further characterizing the tumors’ molecular subtype. An increase in S100A4 immunoexpression by neoplastic luminal mammary cells was associated with an infiltrative tumor mode of growth, consequently leading us to conclude that S100A4 protein could be related to progression in CMCs. Additionally, the occurrence of the luminal A molecular subtype was associated with the complex histotype in CMCs. Although we have demonstrated that changes in S100A4 protein immunoexpression occurs in CMCs, further studies are needed to determine whether this represents important independent biomarkers for CMCs.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent163-169-
dc.language.isoeng-
dc.sourceCurrículo Lattes-
dc.subjectCathepsinen
dc.subjectMammary tumorsen
dc.subjectMetastasis-associated proteinsen
dc.subjectMolecular subtypesen
dc.subjectS100 proteinen
dc.titleImmunoexpression of Cathepsin D and S100A4 protein and their molecular subtyptes in canine mammary carcinomasen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionFundação Antônio Prudente-
dc.contributor.institutionUniversidade do Porto-
dc.description.affiliationFundação Antônio Prudente, Departamento de Anatomia Patológica, Hospital A.C. Camargo-
dc.description.affiliationUniversidade do Porto, Instituto de Patologia e Imunologia Molecular-
dc.description.affiliationUniversidade do Porto, Faculdade de Medicina-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Patologia, Faculdade de Medicina de Botucatu-
dc.description.affiliationUnespUniversidade Estadual Paulista, Departamento de Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia de Botucatu-
dc.description.sponsorshipIdFAPESP: 2008/57309-5-
dc.description.sponsorshipIdFAPESP: 2010/51596-2-
dc.identifier.doi10.4236/ojvm.2012.24026-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofOpen Journal of Veterinary Medicine-
dc.identifier.lattes7877362137164650-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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