Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/141084
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Figueroa, Fernanda Carmelo | - |
dc.contributor.author | Salgado, Breno Souza | - |
dc.contributor.author | Monteiro, Lidianne Narducci | - |
dc.contributor.author | Rocha, Rafael Malagoli | - |
dc.contributor.author | Domingues, Maria Aparecida Custódio | - |
dc.contributor.author | Martins, Diana | - |
dc.contributor.author | Schmitt, Fernando | - |
dc.contributor.author | Rocha, Noeme Sousa | - |
dc.date.accessioned | 2016-07-07T12:36:46Z | - |
dc.date.accessioned | 2016-10-25T21:45:18Z | - |
dc.date.available | 2016-07-07T12:36:46Z | - |
dc.date.available | 2016-10-25T21:45:18Z | - |
dc.date.issued | 2012 | - |
dc.identifier | http://dx.doi.org/10.4236/ojvm.2012.24026 | - |
dc.identifier.citation | Open Journal of Veterinary Medicine, v. 2, n. 4, p. 163-169, 2012. | - |
dc.identifier.issn | 2218-6050 | - |
dc.identifier.uri | http://hdl.handle.net/11449/141084 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/141084 | - |
dc.description.abstract | Cathepsin D (CD), a lysosomal protease, and S100A4 protein, a calcium binding motif, are considered to be involved in metastasis in various human cancers. No data regarding such proteins are available for canine mammary carcinomas (CMCs). Accordingly, their expression in association with known factors of prognosis was investigated in this study. For that, 66 surgically resected CMCs were submitted to an immunohistochemical evaluation using anti CD, S100A4 protein, HER2, estrogen receptor α, cytokeratin 5, and p63 antibodies, further characterizing the tumors’ molecular subtype. An increase in S100A4 immunoexpression by neoplastic luminal mammary cells was associated with an infiltrative tumor mode of growth, consequently leading us to conclude that S100A4 protein could be related to progression in CMCs. Additionally, the occurrence of the luminal A molecular subtype was associated with the complex histotype in CMCs. Although we have demonstrated that changes in S100A4 protein immunoexpression occurs in CMCs, further studies are needed to determine whether this represents important independent biomarkers for CMCs. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 163-169 | - |
dc.language.iso | eng | - |
dc.source | Currículo Lattes | - |
dc.subject | Cathepsin | en |
dc.subject | Mammary tumors | en |
dc.subject | Metastasis-associated proteins | en |
dc.subject | Molecular subtypes | en |
dc.subject | S100 protein | en |
dc.title | Immunoexpression of Cathepsin D and S100A4 protein and their molecular subtyptes in canine mammary carcinomas | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Fundação Antônio Prudente | - |
dc.contributor.institution | Universidade do Porto | - |
dc.description.affiliation | Fundação Antônio Prudente, Departamento de Anatomia Patológica, Hospital A.C. Camargo | - |
dc.description.affiliation | Universidade do Porto, Instituto de Patologia e Imunologia Molecular | - |
dc.description.affiliation | Universidade do Porto, Faculdade de Medicina | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista, Departamento de Patologia, Faculdade de Medicina de Botucatu | - |
dc.description.affiliationUnesp | Universidade Estadual Paulista, Departamento de Clínica Veterinária, Faculdade de Medicina Veterinária e Zootecnia de Botucatu | - |
dc.description.sponsorshipId | FAPESP: 2008/57309-5 | - |
dc.description.sponsorshipId | FAPESP: 2010/51596-2 | - |
dc.identifier.doi | 10.4236/ojvm.2012.24026 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Open Journal of Veterinary Medicine | - |
dc.identifier.lattes | 7877362137164650 | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.