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http://acervodigital.unesp.br/handle/11449/1422
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DC Field | Value | Language |
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dc.contributor.author | Saraiva, Juliana | - |
dc.contributor.author | Moreira Lira, Ana Amelia | - |
dc.contributor.author | Esperandim, Viviane Rodrigues | - |
dc.contributor.author | Ferreira, Daniele da Silva | - |
dc.contributor.author | Ferraudo, Antonio Sergio | - |
dc.contributor.author | Bastos, Jairo Kenupp | - |
dc.contributor.author | Andrade e Silva, Marcio Luis | - |
dc.contributor.author | de Gaitani, Cristiane Masetto | - |
dc.contributor.author | de Albuquerque, Sergio | - |
dc.contributor.author | Marchetti, Juliana Maldonado | - |
dc.date.accessioned | 2014-05-20T13:13:43Z | - |
dc.date.accessioned | 2016-10-25T16:34:34Z | - |
dc.date.available | 2014-05-20T13:13:43Z | - |
dc.date.available | 2016-10-25T16:34:34Z | - |
dc.date.issued | 2010-02-01 | - |
dc.identifier | http://dx.doi.org/10.1007/s00436-010-1725-1 | - |
dc.identifier.citation | Parasitology Research. New York: Springer, v. 106, n. 3, p. 703-708, 2010. | - |
dc.identifier.issn | 0932-0113 | - |
dc.identifier.uri | http://hdl.handle.net/11449/1422 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/1422 | - |
dc.description.abstract | The (-)-hinokinin display high activity against Trypanosoma cruzi in vitro and in vivo. (-)-Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles were prepared and characterized in order to protect (-)-hinokinin of biological interactions and promote its sustained release for treatment of Chagas disease. The microparticles contain (-)-hinokinin were prepared by the classical method of the emulsion/solvent evaporation. The scanning electron microscopy, light-scattering analyzer were used to study the morphology and particle size, respectively. The encapsulation efficiency was determined, drug release studies were kinetically evaluated, and the trypanocidal effect was evaluated in vivo. (-)-Hinokinin-loaded microparticles obtained showed a mean diameter of 0.862 A mu m with smooth surface and spherical shape. The encapsulation efficiency was 72.46 A +/- 2.92% and developed system maintained drug release with Higuchi kinetics. The preparation method showed to be suitable, since the morphological characteristics, encapsulation efficiency, and in vitro release profile were satisfactory. In vivo assays showed significant reduction of mice parasitaemia after administration of (-)-hinokinin-loaded microparticles. Thus, the developed microparticles seem to be a promising system for sustained release of (-)-hinokinin for treatment of Chagas disease. | en |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 703-708 | - |
dc.language.iso | eng | - |
dc.publisher | Springer | - |
dc.source | Web of Science | - |
dc.title | (-)-Hinokinin-loaded poly(d,l-lactide-co-glycolide) microparticles for Chagas disease | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Franca | - |
dc.description.affiliation | Univ São Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Ciencias Agr & Vet Jaboticabal, BR-14884900 Jaboticabal, SP, Brazil | - |
dc.description.affiliation | Univ Franca, Nucleo Pesquisa Ciencias Exatas & Tecnol, BR-14404600 Franca, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Ciencias Agr & Vet Jaboticabal, BR-14884900 Jaboticabal, SP, Brazil | - |
dc.identifier.doi | 10.1007/s00436-010-1725-1 | - |
dc.identifier.wos | WOS:000274252400022 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Parasitology Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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