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dc.contributor.authorGarcia, Denny Marcos-
dc.contributor.authorMessias, Andre-
dc.contributor.authorCosta, Luciana Oliveira-
dc.contributor.authorPinto, Carolina Trindade-
dc.contributor.authorBarbosa, Jose Carlos-
dc.contributor.authorVelasco Cruz, Antonio Augusto-
dc.identifier.citationCurrent Eye Research. Philadelphia: Taylor & Francis Inc, v. 35, n. 6, p. 459-465, 2010.-
dc.description.abstractPurpose: To describe spontaneous blink kinematics in Graves' upper eyelid retraction (UER).Methods: The magnetic search coil technique was used to record spontaneous blinks of 15 healthy subjects (aged 23-56 years, 15 eyelids) and 15 patients with Graves' UER (aged 22-62 years, 15 eyelids) during a 5-min period of video observation, and the signals were digitized at 200 Hz (12 bits). Overall, a total of 2,798 blinks were recorded for the controls and 1,860 for the patients. The distance between pupil center and upper eyelid margin in the primary position of gaze (MRD) was measured with the Image J software.Results: The blinking rate of patients was lower than that of control subjects, with a mean (+/-SEM) blinking rate (blinks/min) of 13.0 +/- 1.7 for patients and of 20.0 +/- 2.1 for the controls (t = 2.58, P = 0.016). There were no statistically significant differences in blink amplitude between controls (22.7 +/- 3.1 degrees) and Graves' patients (24.7 +/- 3.3 degrees). However, while only 22% of the blinks performed by controls were smaller than MRD, this rate was 78% for patients. In addition, in blinks larger than 25, patients showed lower down-phase velocity than controls.Conclusions: Patients with Graves' UER show reduced blinks rates and abnormal blink kinematics, which might be related to the development of exposure keratitis in this disease.en
dc.publisherTaylor & Francis Inc-
dc.sourceWeb of Science-
dc.subjectGraves' orbitopathyen
dc.subjectEyelid retractionen
dc.subjectMagnetic search coilen
dc.subjectBlink kinematicsen
dc.titleSpontaneous Blinking in Patients With Graves' Upper Eyelid Retractionen
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv São Paulo, Sch Med Ribeirao Preto, Dept Ophthalmol Otorhinolaryngol & Head & Neck Su, BR-14049900 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Dept Exact Sci, UNESP, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Exact Sci, UNESP, São Paulo, Brazil-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofCurrent Eye Research-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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