You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/14899
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBadial, Peres R.-
dc.contributor.authorOliveira-Filho, Jose P.-
dc.contributor.authorCunha, Paulo Henrique J.-
dc.contributor.authorAraujo, Joao P.-
dc.contributor.authorPeiró, Juliana Regina-
dc.contributor.authorDivers, Thomas J.-
dc.contributor.authorWinand, Nena J.-
dc.contributor.authorBorges, Alexandre Secorun-
dc.date.accessioned2013-09-30T18:38:05Z-
dc.date.accessioned2014-05-20T13:42:52Z-
dc.date.accessioned2016-10-25T16:57:32Z-
dc.date.available2013-09-30T18:38:05Z-
dc.date.available2014-05-20T13:42:52Z-
dc.date.available2016-10-25T16:57:32Z-
dc.date.issued2011-05-15-
dc.identifierhttp://dx.doi.org/10.1016/j.vetimm.2011.02.009-
dc.identifier.citationVeterinary Immunology and Immunopathology. Amsterdam: Elsevier B.V., v. 141, n. 1-2, p. 157-161, 2011.-
dc.identifier.issn0165-2427-
dc.identifier.urihttp://hdl.handle.net/11449/14899-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/14899-
dc.description.abstractHepcidin is a highly conserved disulfide-bonded peptide that plays a central role in iron homeostasis. During systemic inflammation, hepcidin up-regulation is responsible for hypoferremia. This study aimed to analyze the influence of the inflammatory process induced by complete Freund's adjuvant (CFA) or lipopolysaccharide (LPS) on the liver expression of hepcidin mRNA transcripts and plasma iron concentration of sheep. The expression levels of hepcidin transcripts were up-regulated after CFA or LPS. Hypoferremic response was observed at 12 h (15.46 +/- 6.05 mu mol/L) or 6 h (14.59 +/- 4.38 mu mol/L) and iron reached its lowest level at 96 h (3.08 +/- 1.18 mu mol/L) or 16 h (4.06 +/- 1.58 mu mol/L) after CFA administration or LPS infusion, respectively. This study demonstrated that the iron regulatory hormone hepcidin was up-regulated in sheep liver in response to systemic inflammation. These findings extend our knowledge on the relationship between the systemic inflammatory response, hepcidin and iron, and provide a starting point for additional studies on iron metabolism and the inflammatory process in sheep. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipBBSRC-
dc.description.sponsorshipMerial Animal Health-
dc.format.extent157-161-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectSheepen
dc.subjectHepcidinen
dc.subjectComplete Freund's adjuvanten
dc.subjectLipopolysaccharideen
dc.subjectSystemic inflammationen
dc.subjectHypoferremiaen
dc.titleInfluence of experimental inflammatory response on hepatic hepcidin gene expression and plasma iron concentration in sheepen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionCornell Univ-
dc.description.affiliationUniv Estadual Paulista UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista UNESP, Inst Biosci, Dept Immunol & Microbiol, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista UNESP, Sch Vet Med, Dept Clin Surg & Anim Reprod, Aracatuba, SP, Brazil-
dc.description.affiliationCornell Univ, Coll Vet Med, Dept Clin Sci, Ithaca, NY 14853 USA-
dc.description.affiliationCornell Univ, Coll Vet Med, Dept Mol Med, Ithaca, NY 14853 USA-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Inst Biosci, Dept Immunol & Microbiol, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Sch Vet Med, Dept Clin Surg & Anim Reprod, Aracatuba, SP, Brazil-
dc.identifier.doi10.1016/j.vetimm.2011.02.009-
dc.identifier.wosWOS:000290188200021-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofVeterinary Immunology and Immunopathology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.