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DC Field | Value | Language |
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dc.contributor.author | Badial, Peres R. | - |
dc.contributor.author | Oliveira-Filho, Jose P. | - |
dc.contributor.author | Cunha, Paulo Henrique J. | - |
dc.contributor.author | Araujo, Joao P. | - |
dc.contributor.author | Peiró, Juliana Regina | - |
dc.contributor.author | Divers, Thomas J. | - |
dc.contributor.author | Winand, Nena J. | - |
dc.contributor.author | Borges, Alexandre Secorun | - |
dc.date.accessioned | 2013-09-30T18:38:05Z | - |
dc.date.accessioned | 2014-05-20T13:42:52Z | - |
dc.date.accessioned | 2016-10-25T16:57:32Z | - |
dc.date.available | 2013-09-30T18:38:05Z | - |
dc.date.available | 2014-05-20T13:42:52Z | - |
dc.date.available | 2016-10-25T16:57:32Z | - |
dc.date.issued | 2011-05-15 | - |
dc.identifier | http://dx.doi.org/10.1016/j.vetimm.2011.02.009 | - |
dc.identifier.citation | Veterinary Immunology and Immunopathology. Amsterdam: Elsevier B.V., v. 141, n. 1-2, p. 157-161, 2011. | - |
dc.identifier.issn | 0165-2427 | - |
dc.identifier.uri | http://hdl.handle.net/11449/14899 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/14899 | - |
dc.description.abstract | Hepcidin is a highly conserved disulfide-bonded peptide that plays a central role in iron homeostasis. During systemic inflammation, hepcidin up-regulation is responsible for hypoferremia. This study aimed to analyze the influence of the inflammatory process induced by complete Freund's adjuvant (CFA) or lipopolysaccharide (LPS) on the liver expression of hepcidin mRNA transcripts and plasma iron concentration of sheep. The expression levels of hepcidin transcripts were up-regulated after CFA or LPS. Hypoferremic response was observed at 12 h (15.46 +/- 6.05 mu mol/L) or 6 h (14.59 +/- 4.38 mu mol/L) and iron reached its lowest level at 96 h (3.08 +/- 1.18 mu mol/L) or 16 h (4.06 +/- 1.58 mu mol/L) after CFA administration or LPS infusion, respectively. This study demonstrated that the iron regulatory hormone hepcidin was up-regulated in sheep liver in response to systemic inflammation. These findings extend our knowledge on the relationship between the systemic inflammatory response, hepcidin and iron, and provide a starting point for additional studies on iron metabolism and the inflammatory process in sheep. (C) 2011 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | BBSRC | - |
dc.description.sponsorship | Merial Animal Health | - |
dc.format.extent | 157-161 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Sheep | en |
dc.subject | Hepcidin | en |
dc.subject | Complete Freund's adjuvant | en |
dc.subject | Lipopolysaccharide | en |
dc.subject | Systemic inflammation | en |
dc.subject | Hypoferremia | en |
dc.title | Influence of experimental inflammatory response on hepatic hepcidin gene expression and plasma iron concentration in sheep | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Cornell Univ | - |
dc.description.affiliation | Univ Estadual Paulista UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista UNESP, Inst Biosci, Dept Immunol & Microbiol, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista UNESP, Sch Vet Med, Dept Clin Surg & Anim Reprod, Aracatuba, SP, Brazil | - |
dc.description.affiliation | Cornell Univ, Coll Vet Med, Dept Clin Sci, Ithaca, NY 14853 USA | - |
dc.description.affiliation | Cornell Univ, Coll Vet Med, Dept Mol Med, Ithaca, NY 14853 USA | - |
dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Inst Biosci, Dept Immunol & Microbiol, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista UNESP, Sch Vet Med, Dept Clin Surg & Anim Reprod, Aracatuba, SP, Brazil | - |
dc.identifier.doi | 10.1016/j.vetimm.2011.02.009 | - |
dc.identifier.wos | WOS:000290188200021 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Veterinary Immunology and Immunopathology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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