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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/157
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dc.contributor.authorGrillo, Renato-
dc.contributor.authorMelo, Nathalie F. S. de-
dc.contributor.authorFraceto, Leonardo Fernandes-
dc.contributor.authorBrito, Charles L.-
dc.contributor.authorTrossini, Gustavo H. G.-
dc.contributor.authorMenezes, Carla M. S.-
dc.contributor.authorFerreira, Elizabeth Igne-
dc.contributor.authorMoraes, Carolina Morales-
dc.date.accessioned2014-05-20T13:12:10Z-
dc.date.available2014-05-20T13:12:10Z-
dc.date.issued2008-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S0100-40422008000200019-
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 31, n. 2, p. 290-295, 2008.-
dc.identifier.issn0100-4042-
dc.identifier.urihttp://hdl.handle.net/11449/157-
dc.description.abstractHydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-beta-cyclodextrin (HP-beta-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-beta-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (deltaGº= 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent290-295-
dc.language.isopor-
dc.publisherSociedade Brasileira de Química-
dc.sourceSciELO-
dc.subjecthydroxymethylnitrofurazoneen
dc.subjectcyclodextrinen
dc.subjectinclusion complexen
dc.titleCaracterização físico-química de complexo de inclusão entre hidroximetilnitrofurazona e hidroxipropil-beta-ciclodextrinapt
dc.title.alternativePhysico-chemical characterization of inclusion complex between hydroxymethylnitrofurazone and hydroxypropyl-beta-cyclodextrinen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental-
dc.description.affiliationUniversidade de São Paulo Faculdade de Ciências Farmacêuticas-
dc.description.affiliationUniversidade Estadual de Campinas Instituto de Biologia Departamento de Bioquímica-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Engenharia Ambiental-
dc.identifier.doi10.1590/S0100-40422008000200019-
dc.identifier.scieloS0100-40422008000200019-
dc.identifier.wosWOS:000254295500019-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS0100-40422008000200019.pdf-
dc.relation.ispartofQuímica Nova-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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