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http://acervodigital.unesp.br/handle/11449/15814
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DC Field | Value | Language |
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dc.contributor.author | Martins, VCA | - |
dc.contributor.author | Goissis, G. | - |
dc.contributor.author | Ribeiro, A. C. | - |
dc.contributor.author | Marcantonio, E. | - |
dc.contributor.author | Bet, M. R. | - |
dc.date.accessioned | 2014-02-26T17:02:30Z | - |
dc.date.accessioned | 2014-05-20T13:45:03Z | - |
dc.date.accessioned | 2016-10-25T16:59:08Z | - |
dc.date.available | 2014-02-26T17:02:30Z | - |
dc.date.available | 2014-05-20T13:45:03Z | - |
dc.date.available | 2016-10-25T16:59:08Z | - |
dc.date.issued | 1998-03-01 | - |
dc.identifier | http://dx.doi.org/10.1046/j.1525-1594.1998.06004.x | - |
dc.identifier.citation | Artificial Organs. Malden: Blackwell Science Inc., v. 22, n. 3, p. 215-221, 1998. | - |
dc.identifier.issn | 0160-564X | - |
dc.identifier.uri | http://hdl.handle.net/11449/15814 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/15814 | - |
dc.description.abstract | Major problems with the treatment of osteomyelitis are associated with poor antibiotic distribution at the site of infection due to limited blood circulation to the skeletal tissue. Improved treatment procedures have been used in drug delivery systems that include bioceramics and natural and synthetic polymers. This work reports the development of anionic collagen:hydroxyapatite composite paste for sustained antibiotic release. Antibiotic release by the composite was characterized by two steps. In the first, 15.0 +/- 4.9% was released in the first 5 h (n = 53) by a normal Fick diffusion mechanism. In the second step, only 16.8 +/- 2.2% was released after 7 days. In conclusion, hydroxyapatite:anionic collagen composite can be an efficient support for sustained antibiotic release in the treatment of osteomyelitis because most of the antibiotic release may be associated with composite bioresorption, thus permitting antibiotic release throughout the healing process. Hydroxyapatite:anionic collagen paste showed good biocompatibility associated with bone tissue growth with material still being observed after 60 days from the time of implants. | en |
dc.format.extent | 215-221 | - |
dc.language.iso | eng | - |
dc.publisher | Blackwell Science | - |
dc.source | Web of Science | - |
dc.subject | antibiotic | pt |
dc.subject | release | pt |
dc.subject | anionic collagen | pt |
dc.subject | hydroxyapatite | pt |
dc.subject | composite | pt |
dc.subject | paste | pt |
dc.title | The controlled release of antibiotic by hydroxyapatite: Anionic collagen composites | en |
dc.type | outro | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ São Paulo, Inst Quim Sao Carlos, Dept Quim & Fis Mol, BR-13560250 São Paulo, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Odontol Araraquara, Dept Diagnost & Cirurgia, São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Odontol Araraquara, Dept Diagnost & Cirurgia, São Paulo, Brazil | - |
dc.identifier.doi | 10.1046/j.1525-1594.1998.06004.x | - |
dc.identifier.wos | WOS:000072313200010 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Artificial Organs | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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