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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/15814
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dc.contributor.authorMartins, VCA-
dc.contributor.authorGoissis, G.-
dc.contributor.authorRibeiro, A. C.-
dc.contributor.authorMarcantonio, E.-
dc.contributor.authorBet, M. R.-
dc.date.accessioned2014-02-26T17:02:30Z-
dc.date.accessioned2014-05-20T13:45:03Z-
dc.date.accessioned2016-10-25T16:59:08Z-
dc.date.available2014-02-26T17:02:30Z-
dc.date.available2014-05-20T13:45:03Z-
dc.date.available2016-10-25T16:59:08Z-
dc.date.issued1998-03-01-
dc.identifierhttp://dx.doi.org/10.1046/j.1525-1594.1998.06004.x-
dc.identifier.citationArtificial Organs. Malden: Blackwell Science Inc., v. 22, n. 3, p. 215-221, 1998.-
dc.identifier.issn0160-564X-
dc.identifier.urihttp://hdl.handle.net/11449/15814-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/15814-
dc.description.abstractMajor problems with the treatment of osteomyelitis are associated with poor antibiotic distribution at the site of infection due to limited blood circulation to the skeletal tissue. Improved treatment procedures have been used in drug delivery systems that include bioceramics and natural and synthetic polymers. This work reports the development of anionic collagen:hydroxyapatite composite paste for sustained antibiotic release. Antibiotic release by the composite was characterized by two steps. In the first, 15.0 +/- 4.9% was released in the first 5 h (n = 53) by a normal Fick diffusion mechanism. In the second step, only 16.8 +/- 2.2% was released after 7 days. In conclusion, hydroxyapatite:anionic collagen composite can be an efficient support for sustained antibiotic release in the treatment of osteomyelitis because most of the antibiotic release may be associated with composite bioresorption, thus permitting antibiotic release throughout the healing process. Hydroxyapatite:anionic collagen paste showed good biocompatibility associated with bone tissue growth with material still being observed after 60 days from the time of implants.en
dc.format.extent215-221-
dc.language.isoeng-
dc.publisherBlackwell Science-
dc.sourceWeb of Science-
dc.subjectantibioticpt
dc.subjectreleasept
dc.subjectanionic collagenpt
dc.subjecthydroxyapatitept
dc.subjectcompositept
dc.subjectpastept
dc.titleThe controlled release of antibiotic by hydroxyapatite: Anionic collagen compositesen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv São Paulo, Inst Quim Sao Carlos, Dept Quim & Fis Mol, BR-13560250 São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Fac Odontol Araraquara, Dept Diagnost & Cirurgia, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Fac Odontol Araraquara, Dept Diagnost & Cirurgia, São Paulo, Brazil-
dc.identifier.doi10.1046/j.1525-1594.1998.06004.x-
dc.identifier.wosWOS:000072313200010-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArtificial Organs-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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