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http://acervodigital.unesp.br/handle/11449/15974
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DC Field | Value | Language |
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dc.contributor.author | Corbi, Samia C. T. | - |
dc.contributor.author | Anovazzi, Giovana | - |
dc.contributor.author | Finoti, Livia S. | - |
dc.contributor.author | Kim, Yeon J. | - |
dc.contributor.author | Capela, Marisa Veiga | - |
dc.contributor.author | Secolin, Rodrigo | - |
dc.contributor.author | Marcaccini, Andrea M. | - |
dc.contributor.author | Gerlach, Raquel F. | - |
dc.contributor.author | Orrico, Silvana R. P. | - |
dc.contributor.author | Cirelli, Joni A. | - |
dc.contributor.author | Scarel-Caminaga, Raquel M. | - |
dc.date.accessioned | 2013-09-30T18:31:51Z | - |
dc.date.accessioned | 2014-05-20T13:45:25Z | - |
dc.date.accessioned | 2016-10-25T16:59:26Z | - |
dc.date.available | 2013-09-30T18:31:51Z | - |
dc.date.available | 2014-05-20T13:45:25Z | - |
dc.date.available | 2016-10-25T16:59:26Z | - |
dc.date.issued | 2012-10-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.archoralbio.2012.07.003 | - |
dc.identifier.citation | Archives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 10, p. 1355-1361, 2012. | - |
dc.identifier.issn | 0003-9969 | - |
dc.identifier.uri | http://hdl.handle.net/11449/15974 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/15974 | - |
dc.description.abstract | Objective: Previously, we identified that the ATC/TTC haplotype formed by polymorphisms in the Interleukin-(IL)8 gene conferred susceptibility to chronic periodontitis (CP). The aim of the study was to investigate whether the IL8 haplotype ATC/TTC was associated with the volume of gingival crevicular fluid (GCF), the concentration of interleukin IL-8 in the GCF, as well as periodontal conditions in patients with CP in comparison to controls without CP.Methods: Seventy-nine individuals (CP: n = 41, controls: n = 38) were grouped according to the presence (susceptible for CP) or absence (not susceptible for CP) of the IL8 ATC/TTC haplotype. After periodontal clinical evaluation, they were subdivided by the presence or absence of CP. GCF was collected from each patient and the IL-8 levels were determined by ELISA. The GCF volume of each subject was measured by means of a calibrated electronic device. Comparisons of means between carriers and non-carriers of the ATC/TTC haplotype were evaluated using the Mann-Whitney test. Linear regression and stepwise linear regression analysis were used to analyse the association of the GCF volume with potential covariates and their contribution for the phenotype.Results: We did not find significant differences of both periodontal conditions and IL-8 concentration in the GCF of patients with the presence or absence of the IL8 ATC/TTC haplotype. However, the GCF volume was significantly higher amongst the patients affected by CP that are absent for the IL8 ATC/TTC haplotype. In addition, linear regression analysis showed a statistically significant association between GCF volume and CP, IL8 haplotype ATC/TTC and IL-8 concentration.Conclusions: The IL8 haplotype of susceptibility to CP was neither associated with IL-8 cytokine levels nor with clinical periodontal parameters. Also, CP, IL8 haplotype and IL-8 concentration showed a positive association with the GCF volume levels in the studied patients. (c) 2012 Published by Elsevier Ltd. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.format.extent | 1355-1361 | - |
dc.language.iso | eng | - |
dc.publisher | Pergamon-Elsevier B.V. Ltd | - |
dc.source | Web of Science | - |
dc.subject | Interleukin-8 | en |
dc.subject | Chronic periodontitis | en |
dc.subject | Disease susceptibility | en |
dc.subject | Gingival crevicular fluid | en |
dc.title | Haplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene do not influence protein level in the gingival crevicular fluid | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Universidade de São Paulo (USP) | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.description.affiliation | UNESP São Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, Araraquara, SP, Brazil | - |
dc.description.affiliation | UNESP São Paulo State Univ, Inst Chem Araraquara, Dept Phys Chem, Araraquara, SP, Brazil | - |
dc.description.affiliation | Univ São Paulo, Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, Ribeirao Preto, SP, Brazil | - |
dc.description.affiliation | UNESP São Paulo State Univ, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil | - |
dc.description.affiliation | Univ Campinas UNICAMP, Dept Med Genet, Campinas, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP São Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP São Paulo State Univ, Inst Chem Araraquara, Dept Phys Chem, Araraquara, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP São Paulo State Univ, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil | - |
dc.description.sponsorshipId | FAPESP: 03/10424-0 | - |
dc.description.sponsorshipId | FAPESP: 09/08773-3 | - |
dc.identifier.doi | 10.1016/j.archoralbio.2012.07.003 | - |
dc.identifier.wos | WOS:000310409400008 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Archives of Oral Biology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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