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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/15974
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dc.contributor.authorCorbi, Samia C. T.-
dc.contributor.authorAnovazzi, Giovana-
dc.contributor.authorFinoti, Livia S.-
dc.contributor.authorKim, Yeon J.-
dc.contributor.authorCapela, Marisa Veiga-
dc.contributor.authorSecolin, Rodrigo-
dc.contributor.authorMarcaccini, Andrea M.-
dc.contributor.authorGerlach, Raquel F.-
dc.contributor.authorOrrico, Silvana R. P.-
dc.contributor.authorCirelli, Joni A.-
dc.contributor.authorScarel-Caminaga, Raquel M.-
dc.date.accessioned2013-09-30T18:31:51Z-
dc.date.accessioned2014-05-20T13:45:25Z-
dc.date.accessioned2016-10-25T16:59:26Z-
dc.date.available2013-09-30T18:31:51Z-
dc.date.available2014-05-20T13:45:25Z-
dc.date.available2016-10-25T16:59:26Z-
dc.date.issued2012-10-01-
dc.identifierhttp://dx.doi.org/10.1016/j.archoralbio.2012.07.003-
dc.identifier.citationArchives of Oral Biology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 10, p. 1355-1361, 2012.-
dc.identifier.issn0003-9969-
dc.identifier.urihttp://hdl.handle.net/11449/15974-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/15974-
dc.description.abstractObjective: Previously, we identified that the ATC/TTC haplotype formed by polymorphisms in the Interleukin-(IL)8 gene conferred susceptibility to chronic periodontitis (CP). The aim of the study was to investigate whether the IL8 haplotype ATC/TTC was associated with the volume of gingival crevicular fluid (GCF), the concentration of interleukin IL-8 in the GCF, as well as periodontal conditions in patients with CP in comparison to controls without CP.Methods: Seventy-nine individuals (CP: n = 41, controls: n = 38) were grouped according to the presence (susceptible for CP) or absence (not susceptible for CP) of the IL8 ATC/TTC haplotype. After periodontal clinical evaluation, they were subdivided by the presence or absence of CP. GCF was collected from each patient and the IL-8 levels were determined by ELISA. The GCF volume of each subject was measured by means of a calibrated electronic device. Comparisons of means between carriers and non-carriers of the ATC/TTC haplotype were evaluated using the Mann-Whitney test. Linear regression and stepwise linear regression analysis were used to analyse the association of the GCF volume with potential covariates and their contribution for the phenotype.Results: We did not find significant differences of both periodontal conditions and IL-8 concentration in the GCF of patients with the presence or absence of the IL8 ATC/TTC haplotype. However, the GCF volume was significantly higher amongst the patients affected by CP that are absent for the IL8 ATC/TTC haplotype. In addition, linear regression analysis showed a statistically significant association between GCF volume and CP, IL8 haplotype ATC/TTC and IL-8 concentration.Conclusions: The IL8 haplotype of susceptibility to CP was neither associated with IL-8 cytokine levels nor with clinical periodontal parameters. Also, CP, IL8 haplotype and IL-8 concentration showed a positive association with the GCF volume levels in the studied patients. (c) 2012 Published by Elsevier Ltd.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent1355-1361-
dc.language.isoeng-
dc.publisherPergamon-Elsevier B.V. Ltd-
dc.sourceWeb of Science-
dc.subjectInterleukin-8en
dc.subjectChronic periodontitisen
dc.subjectDisease susceptibilityen
dc.subjectGingival crevicular fluiden
dc.titleHaplotypes of susceptibility to chronic periodontitis in the Interleukin 8 gene do not influence protein level in the gingival crevicular fluiden
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.description.affiliationUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, Araraquara, SP, Brazil-
dc.description.affiliationUNESP São Paulo State Univ, Inst Chem Araraquara, Dept Phys Chem, Araraquara, SP, Brazil-
dc.description.affiliationUniv São Paulo, Dent Sch Ribeirao Preto, Dept Morphol Stomatol & Physiol, Ribeirao Preto, SP, Brazil-
dc.description.affiliationUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil-
dc.description.affiliationUniv Campinas UNICAMP, Dept Med Genet, Campinas, SP, Brazil-
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP São Paulo State Univ, Inst Chem Araraquara, Dept Phys Chem, Araraquara, SP, Brazil-
dc.description.affiliationUnespUNESP São Paulo State Univ, Sch Dent Araraquara, Dept Morphol, Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 03/10424-0-
dc.description.sponsorshipIdFAPESP: 09/08773-3-
dc.identifier.doi10.1016/j.archoralbio.2012.07.003-
dc.identifier.wosWOS:000310409400008-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofArchives of Oral Biology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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