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http://acervodigital.unesp.br/handle/11449/15998
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DC Field | Value | Language |
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dc.contributor.author | Mawardi, H. | - |
dc.contributor.author | Giro, G. | - |
dc.contributor.author | Kajiya, M. | - |
dc.contributor.author | Ohta, K. | - |
dc.contributor.author | Almazrooa, S. | - |
dc.contributor.author | Alshwaimi, E. | - |
dc.contributor.author | Woo, S-B. | - |
dc.contributor.author | Nishimura, I. | - |
dc.contributor.author | Kawai, T. | - |
dc.date.accessioned | 2013-09-30T18:31:56Z | - |
dc.date.accessioned | 2014-05-20T13:45:28Z | - |
dc.date.accessioned | 2016-10-25T16:59:29Z | - |
dc.date.available | 2013-09-30T18:31:56Z | - |
dc.date.available | 2014-05-20T13:45:28Z | - |
dc.date.available | 2016-10-25T16:59:29Z | - |
dc.date.issued | 2011-11-01 | - |
dc.identifier | http://dx.doi.org/10.1177/0022034511420430 | - |
dc.identifier.citation | Journal of Dental Research. Thousand Oaks: Sage Publications Inc, v. 90, n. 11, p. 1339-1345, 2011. | - |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | http://hdl.handle.net/11449/15998 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/15998 | - |
dc.description.abstract | No consensus has yet been reached to associate oral bacteria conclusively with the etio-pathogenesis of bisphosphonate-induced osteonecrosis of the jaw (BONJ). Therefore, the present study examined the effects of oral bacteria on the development of BONJ-like lesions in a mouse model. In the pamidronate (Pam)-treated mice, but not control non-drug-treated mice, tooth extraction followed by oral infection with Fusobacterium nucleatum caused BONJ-like lesions and delayed epithelial healing, both of which were completely suppressed by a broad-spectrum antibiotic cocktail. Furthermore, in both in vitro and in vivo experiments, the combination of Pam and Fusobacterium nucleatum caused the death of gingival fibroblasts (GFs) and down-regulated their production of keratinocyte growth factor (KGF), which induces epithelial cell growth and migration. Therefore, in periodontal tissues pre-exposed to bisphosphonate, bacterial infection at tooth extraction sites caused diminished KGF expression in GFs, leading to a delay in the epithelial wound-healing process that was mitigated by antibiotics. | en |
dc.description.sponsorship | NIH from the NIDCR | - |
dc.format.extent | 1339-1345 | - |
dc.language.iso | eng | - |
dc.publisher | Sage Publications Inc | - |
dc.source | Web of Science | - |
dc.subject | bisphosphonate-induced osteonecrosis of the jaw | en |
dc.subject | pamidronate | en |
dc.subject | gingival fibroblast | en |
dc.subject | KGF | en |
dc.subject | wound healing | en |
dc.subject | Fusobacterium nucleatum | en |
dc.title | A Role of Oral Bacteria in Bisphosphonate-induced Osteonecrosis of the Jaw | en |
dc.type | outro | - |
dc.contributor.institution | Forsyth Inst | - |
dc.contributor.institution | Harvard Univ | - |
dc.contributor.institution | King Abdulaziz Univ | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Dammam | - |
dc.contributor.institution | UCLA Sch Dent | - |
dc.description.affiliation | Forsyth Inst, Dept Immunol, Cambridge, MA 02142 USA | - |
dc.description.affiliation | Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Boston, MA 02115 USA | - |
dc.description.affiliation | King Abdulaziz Univ, Oral Med Div, Fac Dent, Jeddah 21589, Saudi Arabia | - |
dc.description.affiliation | UNESP São Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 São Paulo, SP, Brazil | - |
dc.description.affiliation | Univ Dammam, Coll Dent, Restorat Dent Sci Dept, Dammam 31441, Saudi Arabia | - |
dc.description.affiliation | UCLA Sch Dent, Div Adv Prosthodont Biomat & Hosp Dent, Los Angeles, CA 90095 USA | - |
dc.description.affiliationUnesp | UNESP São Paulo State Univ, Sch Dent Araraquara, Dept Oral Diag & Surg, BR-14801903 São Paulo, SP, Brazil | - |
dc.description.sponsorshipId | NIH: DE-18499 | - |
dc.description.sponsorshipId | NIH from the NIDCR: DE-19917 | - |
dc.identifier.doi | 10.1177/0022034511420430 | - |
dc.identifier.wos | WOS:000295692600013 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Dental Research | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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