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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/16282
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dc.contributor.authorAndrade, Carina A. F. de-
dc.contributor.authorAndrade, Glaucia M. F. de-
dc.contributor.authorDe Paula, Patricia M.-
dc.contributor.authorDe Luca, Laurival A.-
dc.contributor.authorMenani, José Vanderlei-
dc.date.accessioned2014-05-20T13:46:06Z-
dc.date.accessioned2016-10-25T16:59:56Z-
dc.date.available2014-05-20T13:46:06Z-
dc.date.available2016-10-25T16:59:56Z-
dc.date.issued2009-04-01-
dc.identifierhttp://dx.doi.org/10.1016/j.ejphar.2009.01.039-
dc.identifier.citationEuropean Journal of Pharmacology. Amsterdam: Elsevier B.V., v. 607, n. 1-3, p. 60-67, 2009.-
dc.identifier.issn0014-2999-
dc.identifier.urihttp://hdl.handle.net/11449/16282-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/16282-
dc.description.abstractMoxonidine (alpha(2)-adrenoceptor/imidazoline receptor agonist) injected into the lateral ventricle induces diuresis, natriuresis and renal vasodilation. Moxonidine-induced diuresis and natriuresis depend on central imidazoline receptors, while central alpha(1)-adrenoceptors are involved in renal vasodilation. However, the involvement of central alpha(1)-adrenoceptors on diuresis and natriuresis to central moxonidine was not investigated yet. In the present study, the effects of moxonidine, alpha-methylnoradrenaline (alpha(2)-adrenoceptor agonist) or phenylephrine (alpha(1)-adrenoceptor agonist) alone or combined with previous injections of prazosin (alpha(1)-adrenoceptor antagonist), yohimbine or RX 821002 (alpha(2)-adrenoceptor antagonists) intracerebroventricularly (i.c.v.) on urinary sodium, potassium and volume were investigated. Male Holtzman rats (n = 5-18/group) with stainless steel cannula implanted into the lateral ventricle and submitted to gastric water load (10% of body weight) were used. Injections of moxonidine (20 nmol) or alpha-methylnoradrenaline (80 nmol) i.c.v. induced natriuresis (196 +/- 25 and 171 +/- 30, respectively, vs. vehicle: 101 +/- 9 mu Eq/2 h) and diuresis (9.0 +/- 0.4 and 12.3 +/- 1.6, respectively, vs. vehicle: 5.2 +/- 0.5 ml/2 h). Pre-treatment with prazosin (320 nmol) i.c.v. abolished the natriuresis (23 +/- 4 and 76 +/- 11 mu Eq/2 h, respectively) and diuresis (5 +/- 1 and 7.6 +/- 0.8 ml/2 h, respectively) produced by i.c.v. moxonidine or alpha-methylnoradrenaline. RX 821002 (320 nmol) i.c.v. abolished the natriuretic effect of alpha-methylnoradrenaline, however, yohimbine (320 nmol) did not change renal responses to moxonidine. Phenylephrine (80 nmol) i.c.v. induced natriuresis and kaliuresis that were blocked by prazosin. Therefore, the present data suggest that moxonidine and alpha-methylnoradrenaline acting on central imidazoline receptors and alpha(2)-adrenoceptors, respectively, activate central alpha(1)-adrenergic mechanisms to increase renal excretion. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent60-67-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectSodium excretionen
dc.subjectUrinary excretionen
dc.subjectAdrenoceptoren
dc.subjectRenal excretionen
dc.subjectPrazosinen
dc.titleInvolvement of central alpha(1)-adrenoceptors on renal responses to central moxonidine and alpha-methylnoradrenalineen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 99/01272-5-
dc.description.sponsorshipIdFAPESP: 06/50803-9-
dc.identifier.doi10.1016/j.ejphar.2009.01.039-
dc.identifier.wosWOS:000265123500010-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofEuropean Journal of Pharmacology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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