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dc.contributor.authorCardoso, Leonardo M.-
dc.contributor.authorColombari, Eduardo-
dc.contributor.authorToney, Glenn M.-
dc.date.accessioned2014-05-20T13:46:11Z-
dc.date.accessioned2016-10-25T17:00:00Z-
dc.date.available2014-05-20T13:46:11Z-
dc.date.available2016-10-25T17:00:00Z-
dc.date.issued2012-11-01-
dc.identifierhttp://dx.doi.org/10.1152/japplphysiol.00912.2012-
dc.identifier.citationJournal of Applied Physiology. Bethesda: Amer Physiological Soc, v. 113, n. 9, p. 1423-1431, 2012.-
dc.identifier.issn8750-7587-
dc.identifier.urihttp://hdl.handle.net/11449/16322-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/16322-
dc.description.abstractCardoso LM, Colombari E, Toney GM. Endogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates sympathetic nerve activity responses to L-glutamate. J Appl Physiol 113: 1423-1431, 2012. First published September 13, 2012; doi:10.1152/japplphysiol.00912.2012.-The hypothalamic paraventricular nucleus (PVN) is important for maintenance of sympathetic nerve activity (SNA) and cardiovascular function. PVN-mediated increases of SNA often involve the excitatory amino acid L-glutamate (L-glu), whose actions can be positively and negatively modulated by a variety of factors, including reactive oxygen species. Here, we determined modulatory effects of the highly diffusible reactive oxygen species hydrogen peroxide (H2O2) on responses to PVN L-glu. Renal SNA (RSNA), arterial blood pressure, and heart rate were recorded in anesthetized rats. L-Glu (0.2 nmol in 100 nl) microinjected unilaterally into PVN increased RSNA (P < 0.05), without affecting mean arterial blood pressure or heart rate. Effects of endogenously generated H2O2 were determined by comparing responses to PVN L-glu before and after PVN injection of the catalase inhibitor 3-amino-1,2,4-triazole (ATZ; 100 nmol/200 nl, n = 5). ATZ alone was without effect on recorded variables, but attenuated the increase of RSNA elicited by PVN L-glu (P < 0.05). PVN injection of exogenous H2O2 (5 nmol in 100 nl, n = 4) and vehicle (artificial cerebrospinal fluid) were without affect, but H2O2, like ATZ, attenuated the increase of RSNA to PVN L-glu (P < 0.05). Tonic effects of endogenous H2O2 were determined by PVN injection of polyethylene glycol-catalase (1.0 IU in 200 nl, n = 5). Whereas polyethylene glycol-catalase alone was without effect, increases of RSNA to subsequent PVN injection of L-glu were increased (P < 0.05). From these data, we conclude that PVN H2O2 tonically, but submaximally, suppresses RSNA responses to L-glu, supporting the idea that a change of H2O2 availability within PVN could influence SNA regulation under physiological and/or disease conditions.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Minas Gerais (FAPEMIG)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Naciona de Pesquisa-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipNational Heart, Lung, and Blood Institute-
dc.format.extent1423-1431-
dc.language.isoeng-
dc.publisherAmer Physiological Soc-
dc.sourceWeb of Science-
dc.subjectglutamatergic transmissionen
dc.subjectarterial blood pressureen
dc.subjectreactive oxygen speciesen
dc.subjectcatalaseen
dc.subjectsuperoxide dismutaseen
dc.titleEndogenous hydrogen peroxide in the hypothalamic paraventricular nucleus regulates sympathetic nerve activity responses to L-glutamateen
dc.typeoutro-
dc.contributor.institutionUniv Texas Hlth Sci Ctr San Antonio-
dc.contributor.institutionUniversidade Federal de Ouro Preto (UFOP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USA-
dc.description.affiliationUniv Fed Ouro Preto, Dept Biol Sci, Ouro Preto, MG, Brazil-
dc.description.affiliationSão Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Sch Dent, Dept Physiol & Pathol, São Paulo, Brazil-
dc.description.sponsorshipIdNational Heart, Lung, and Blood Institute: R01 HL 102310-
dc.description.sponsorshipIdNational Heart, Lung, and Blood Institute: PO1 HL088052-
dc.identifier.doi10.1152/japplphysiol.00912.2012-
dc.identifier.wosWOS:000310649200010-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Applied Physiology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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