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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/16340
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dc.contributor.authorMenezes, Miguel F.-
dc.contributor.authorBarbosa, Silas P.-
dc.contributor.authorAndrade, Carina A. F. de-
dc.contributor.authorMenani, José Vanderlei-
dc.contributor.authorDe Paula, Patricia M.-
dc.date.accessioned2014-05-20T13:46:14Z-
dc.date.available2014-05-20T13:46:14Z-
dc.date.issued2011-02-04-
dc.identifierhttp://dx.doi.org/10.1016/j.brainres.2010.11.075-
dc.identifier.citationBrain Research. Amsterdam: Elsevier B.V., v. 1372, p. 49-58, 2011.-
dc.identifier.issn0006-8993-
dc.identifier.urihttp://hdl.handle.net/11449/16340-
dc.description.abstractPurinergic receptors are present in the lateral parabrachial nucleus (LPBN), a pontine structure involved in the control of sodium intake. In the present study, we investigated the effects of alpha,beta-methyleneadenosine 5'-triphosphate (alpha,beta-methylene ATP, selective P2X purinergic agonist) alone or combined with pyridoxalphosphate-6-azophenyl-2',4'-disulfonic acid (PPADS, P2X purinergic antagonist) or suramin (non-selective P2 purinergic antagonist) injected into the LPBN on sodium depletion-induced 1.8% NaCl intake. Male Holtzman rats with stainless steel cannulas implanted into the LPBN were used. Sodium depletion was induced by treating rats with the diuretic furosemide (20 mg/kg of body weight) followed by 24 h of sodium-deficient diet. Bilateral injections of alpha,beta-methylene ATP (2.0 and 4.0 nmol/0.2 mu l) into the LPBN increased sodium depletion-induced 1.8% NaCl intake (25.3 +/- 0.8 and 26.5 +/- 0.9 ml/120 min, respectively, vs. saline: 15.2 +/- 1.3 ml/120 min). PPADS (4 nmol/0.2 mu l) alone into the LPBN did not change 1.8% NaCl intake, however, pretreatment with PPADS into the LPBN abolished the effects of alpha,beta-methylene ATP on 1.8% NaCl intake (16.9 +/- 0.9 ml/120 min). Suramin (2.0 nmol/0.2 mu l) alone into the LPBN reduced sodium depletion-induced 1.8% NaCl intake (5.7 +/- 1.9 ml/120 min, vs. saline: 15.5 +/- 1.1 ml/120 min), without changing 2% sucrose intake or 24 h water deprivation-induced water intake. The combination of suramin and alpha,beta-methylene ATP into the LPBN produced no change of 1.8% NaCl intake (15.2 +/- 1.2 ml/120 min). The results suggest that purinergic P2 receptor activation in the LPBN facilitates NaCl intake, probably by restraining LPBN mechanisms that inhibit sodium intake. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent49-58-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectAdenosine 5 '-triphosphate (ATP)en
dc.subjectSodium appetiteen
dc.subjectSuraminen
dc.subjectPPADSen
dc.subjectalpha,beta-Methylene ATPen
dc.subjectP2 purinergic receptorsen
dc.titlePurinergic mechanisms of lateral parabrachial nucleus facilitate sodium depletion-induced NaCl intakeen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de Alfenas (UNIFAL)-
dc.description.affiliationSão Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil-
dc.description.affiliationFed Univ Alfenas Unifal MG, Inst Biomed Sci, BR-37130000 Alfenas, MG, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Sch Dent, Dept Physiol & Pathol, BR-14801903 Araraquara, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 07/50647-0-
dc.description.sponsorshipIdFAPESP: 08/52757-0-
dc.identifier.doi10.1016/j.brainres.2010.11.075-
dc.identifier.wosWOS:000287293700006-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000287293700006.pdf-
dc.relation.ispartofBrain Research-
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