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dc.contributor.authorde Almeida, Denize E.-
dc.contributor.authorRoveratti, Cristina-
dc.contributor.authorBrito, Fabio L. C.-
dc.contributor.authorGodoy, Guilherme S.-
dc.contributor.authorDuque, Juan C. M.-
dc.contributor.authorBechara, Gervasio Henrique-
dc.contributor.authorLaus, Jose L.-
dc.identifier.citationVeterinary Ophthalmology. Malden: Wiley-blackwell Publishing, Inc, v. 12, n. 4, p. 211-215, 2009.-
dc.description.abstractObjectiveThis study compared the histopathology of canine distemper virus (CDV)-induced keratoconjunctivitis sicca (KCS) to non-infectious KCS in conjunctival tissues.Animals studiedForty mongrel dogs were assigned to three distinct groups: (i) non-infectious KCS (G1, n = 10), (ii) CDV-induced KCS (G2, n = 20), and (iii) healthy animals without any ocular alterations (G3, n = 10).ProcedureIgG titers and physical and ophthalmic examinations (e.g. Schirmer tear test [STT], tonometry, biomicroscopy, indirect biomicroscopy, and fluorescein test) were performed on all dogs. Conjunctival biopsies were collected and examined microscopically.ResultsNon-infectious and CDV-induced KCS demonstrated similar histopathological changes. Both types of KCS correlated with low STT, conjunctival hyperemia, mucopurulent ocular discharge, predominant lymphoplasmacytic infiltration, and acantholysis and keratinization of the ocular surface. G1 had lower conjunctival goblet cell counts than G3. Inclusion bodies were sporadically found in conjunctival samples of dogs from G2. The severity of ocular lesions in G1 and G2 did not correlate with the histopathological findings.ConclusionsDogs with non-infectious and CDV-induced KCS had very similar conjunctival histopathology. Our findings suggest that the pathophysiology of CDV-induced KCS is likely to be the same as non-infectious KCS, that is, a result of lacrimal deficiency and inflammation of the ocular surface.en
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherWiley-Blackwell Publishing, Inc-
dc.sourceWeb of Science-
dc.subjectkeratoconjunctivitis siccaen
dc.titleConjunctival effects of canine distemper virus-induced keratoconjunctivitis siccaen
dc.contributor.institutionUniversity of Michigan-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Rural Fed Pernambuco-
dc.contributor.institutionCtr Univ Monte Serrat-
dc.contributor.institutionUniversidade Federal de Goiás (UFG)-
dc.description.affiliationUniv Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA-
dc.description.affiliationUniv Estadual Paulista, Dept Vet Clin & Surg, Jaboticabal, SP, Brazil-
dc.description.affiliationUniv Rural Fed Pernambuco, Dept Vet Med, Garanhuns, PE, Brazil-
dc.description.affiliationCtr Univ Monte Serrat, Dept Vet Med, Santos, SP, Brazil-
dc.description.affiliationUniversidade Federal de Goiás (UFG), Dept Vet Med, Goiania, Go, Brazil-
dc.description.affiliationUniv Estadual Paulista, Dept Vet Pathol, Jaboticabal, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Vet Clin & Surg, Jaboticabal, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Vet Pathol, Jaboticabal, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 04/04700-8-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofVeterinary Ophthalmology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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