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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/17689
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dc.contributor.authorAmerico, Madileine F.-
dc.contributor.authorMiranda, Jose Ricardo A.-
dc.contributor.authorCora, Luciana A.-
dc.contributor.authorRomeiro, Fernando G.-
dc.date.accessioned2014-05-20T13:49:36Z-
dc.date.accessioned2016-10-25T17:02:02Z-
dc.date.available2014-05-20T13:49:36Z-
dc.date.available2016-10-25T17:02:02Z-
dc.date.issued2009-04-01-
dc.identifierhttp://dx.doi.org/10.1088/0967-3334/30/4/002-
dc.identifier.citationPhysiological Measurement. Bristol: Iop Publishing Ltd, v. 30, n. 4, p. 363-370, 2009.-
dc.identifier.issn0967-3334-
dc.identifier.urihttp://hdl.handle.net/11449/17689-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/17689-
dc.description.abstractDue to the importance of motility in a number of gastrointestinal disorders, efforts have been made to evaluate both gastric motility counterparts: electrical activity and mechanical activity. The present work aimed to propose a new approach, associating AC biosusceptometry (ACB) and electrogastrography (EGG), to noninvasively monitoring mechanical and electrical gastric activity, respectively. Fourteen volunteers ingested a test meal and their gastric activity was evaluated by EGG and ACB at a baseline and after 20 mg of i.v. hyoscine butylbromide. ACB and EGG showed a similar signal pattern and high temporal correlation. Hyoscine butylbromide decreased the mechanical motility index (MI) by 50.9%, while for electrical MI the reduction was 36.5%. Delayed times to onset (mean +/- SD: 50 +/- 15 versus 40 +/- 20 s; P < 0.01) and the inhibitory effect (16 +/- 4 versus 14 +/- 5 min; P < 0.01) were calculated for ACB and EGG, respectively. ACB and EGG emerged due to their interesting nature, noninvasiveness and low cost to evaluate gastric motility. Our approach associating ACB and EGG allowed monitoring and quantification of the effects of an anticholinergic drug in gastric electrical activity and contractile activity in humans.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent363-370-
dc.language.isoeng-
dc.publisherIop Publishing Ltd-
dc.sourceWeb of Science-
dc.subjecthyoscine N-butylbromideen
dc.subjectstomachen
dc.subjectdiagnostic techniques and procedureen
dc.subjecthumansen
dc.subjectdrug therapyen
dc.titleElectrical and mechanical effects of hyoscine butylbromide on the human stomach: a non-invasive approachen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista, São Paulo State Univ, Inst Biociencias, Dept Fis & Biofis, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, São Paulo State Univ, Fac Med, Dept Clin Med, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, São Paulo State Univ, Inst Biociencias, Dept Fis & Biofis, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, São Paulo State Univ, Fac Med, Dept Clin Med, São Paulo, Brazil-
dc.identifier.doi10.1088/0967-3334/30/4/002-
dc.identifier.wosWOS:000264813400003-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPhysiological Measurement-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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