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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/17704
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dc.contributor.authorLuiz-Ferreira, Anderson-
dc.contributor.authorAlves de Almeida, Ana Cristina-
dc.contributor.authorCola, Maira-
dc.contributor.authorBarbastefano, Victor-
dc.contributor.authorAlbino de Almeida, Ana Beatriz-
dc.contributor.authorBatista, Leonia Maria-
dc.contributor.authorFarias-Silva, Elisangela-
dc.contributor.authorPellizzon, Claudia Helena-
dc.contributor.authorHiruma-Lima, Clélia Akiko-
dc.contributor.authorSantos, Lourdes Campaner dos-
dc.contributor.authorVilegas, Wagner-
dc.contributor.authorMonteiro Souza Brito, Alba Regina-
dc.date.accessioned2014-05-20T13:49:39Z-
dc.date.available2014-05-20T13:49:39Z-
dc.date.issued2010-10-01-
dc.identifierhttp://dx.doi.org/10.3390/molecules15107153-
dc.identifier.citationMolecules. Basel: Mdpi Ag, v. 15, n. 10, p. 7153-7166, 2010.-
dc.identifier.issn1420-3049-
dc.identifier.urihttp://hdl.handle.net/11449/17704-
dc.description.abstractLeaves and bark infusions Anacardium humile St. Hil. (Anacardiaceae), known as in Brazil as cajuzinho do cerrado, have been used in folk medicine as an alternative treatment for ulcers and gastritis. This study evaluated the gastroprotective activity of an ethyl acetate extract of the leaves of A. humile (AcF) and the mechanism involved in this gastroprotection. Pretreatment concentrations (50, 100, 200 mg.kg(-1)) were administered by gavage. Following a 60 min. period, all the rats were orally administered 1 mL of absolute ethanol. One hour after the administration of ethanol, all groups were sacrificed, and the gastric ulcer index was calculated. Prostaglandin PGE(2) concentration, gastric adherent mucous, and the participation of nitric oxide (NO) and sulfhydryl compounds in the gastroprotection process were also analyzed using the most effective tested dose (50 mg.kg(-1)). A histological study of the glandular stomach for the evaluation of the epithelial damage and mucus content was also performed. AcF significantly reduced the gastric damage produced by ethanol. This effect was statistically significant for the 50 mg.kg(-1) group compared to control. Also, it significantly increased the PGE(2) (by 10-fold) and mucous production, while pretreatment with NG-nitro-L-arginine methyl ester (L-NAME) or N-ethylmaleimide (NEM) completely abolished the gastroprotection. AcF has a protective effect against ethanol, and this effect, might be due to the augmentation of the protective mechanisms of mucosa.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent7153-7166-
dc.language.isoeng-
dc.publisherMdpi Ag-
dc.sourceWeb of Science-
dc.subjectAnacardium humileen
dc.subjectantiulcer activityen
dc.subjectcytoprotectionen
dc.subjectmedicinal plantsen
dc.titleMechanisms of the Gastric Antiulcerogenic Activity of Anacardium humile St. Hil on Ethanol-Induced Acute Gastric Mucosal Injury in Ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Federal da Paraíba (UFPB)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Campinas, Dept Anat Biol Celular Fisiol & Biofis, Inst Biol, Campinas, SP, Brazil-
dc.description.affiliationUniv Fed Paraiba UFPB, Lab Tecnol Farmaceut, BR-58051970 Joao Pessoa, Paraiba, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Morfol, Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Quim, Dept Quim Organ, Araraquara, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Morfol, Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biociencias, Dept Fisiol, Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Quim, Dept Quim Organ, Araraquara, SP, Brazil-
dc.identifier.doi10.3390/molecules15107153-
dc.identifier.wosWOS:000283587400034-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000283587400034.pdf-
dc.relation.ispartofMolecules-
dc.identifier.orcid0000-0002-8645-3777pt
dc.identifier.orcid0000-0003-3032-2556pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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