Please use this identifier to cite or link to this item:
http://acervodigital.unesp.br/handle/11449/17763
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Buratini, J. | - |
dc.contributor.author | Pinto, M. G. L. | - |
dc.contributor.author | Castilho, A. C. | - |
dc.contributor.author | Amorim, R. L. | - |
dc.contributor.author | Giometti, I. C. | - |
dc.contributor.author | Portela, V. M. | - |
dc.contributor.author | Nicola, E. S. | - |
dc.contributor.author | Price, C. A. | - |
dc.date.accessioned | 2014-05-20T13:49:47Z | - |
dc.date.accessioned | 2016-10-25T17:02:09Z | - |
dc.date.available | 2014-05-20T13:49:47Z | - |
dc.date.available | 2016-10-25T17:02:09Z | - |
dc.date.issued | 2007-10-01 | - |
dc.identifier | http://dx.doi.org/10.1095/biolreprod.107.062273 | - |
dc.identifier.citation | Biology of Reproduction. Madison: Soc Study Reproduction, v. 77, n. 4, p. 743-750, 2007. | - |
dc.identifier.issn | 0006-3363 | - |
dc.identifier.uri | http://hdl.handle.net/11449/17763 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/17763 | - |
dc.description.abstract | Some fibroblast growth factors (FGFs) affect ovarian follicle cell growth and/or differentiation. Whereas many FGFs activate several FGF receptors, FGF7 and FGF10 primarily activate only one, FGFR2B. As FGF7 is produced by bovine theca cells and acts on granulosa cells, we tested the hypothesis that FGF10 may also play a role in folliculogenesis in cattle. Reverse transcription-polymerase chain reaction demonstrated the presence of FGF10 mRNA in the oocytes and theca cells of the antral follicles, as well as in the preantral follicles. FGF10 protein was detected by immunohistochemistry in the oocytes of the preantral and antral follicles, and in the granulosa and theca cells of the antral follicles. FGF10 expression in theca cells changed during follicle development; mRNA abundance decreased with increasing follicular estradiol concentration in healthy follicles, and was lowest in highly atretic follicles. Culturing of granulosa cells in serum-free medium revealed FSH regulation of FGF10 receptor expression. The addition of FGF10 to cultured granulosa cells decreased the level of estradiol but did not alter cell proliferation. These data support a role for FGF10 in signaling to granulosa cells from theca cells and/or the oocyte. | en |
dc.format.extent | 743-750 | - |
dc.language.iso | eng | - |
dc.publisher | Soc Study Reproduction | - |
dc.source | Web of Science | - |
dc.subject | fibroblast growth factors | pt |
dc.subject | follicle | pt |
dc.subject | granulosa cells | pt |
dc.subject | growth factors | pt |
dc.subject | theca cells | pt |
dc.title | Expression and function of fibroblast growth factor 10 and its receptor, fibroblast growth factor receptor 213, in bovine follicles | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Montreal | - |
dc.description.affiliation | Univ Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Vet Med, Dept Reprod Anim, BR-18618000 São Paulo, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista, Fac Vet Med, Dept Clin Vet, BR-18618000 São Paulo, Brazil | - |
dc.description.affiliation | Univ Montreal, Fac Med Vet, Ctr Rech Reprod Anim, Quebec City, PQ J2S 7C6, Canada | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Inst Biociencias, Dept Fisiol, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Vet Med, Dept Reprod Anim, BR-18618000 São Paulo, Brazil | - |
dc.description.affiliationUnesp | Univ Estadual Paulista, Fac Vet Med, Dept Clin Vet, BR-18618000 São Paulo, Brazil | - |
dc.identifier.doi | 10.1095/biolreprod.107.062273 | - |
dc.identifier.wos | WOS:000249766700018 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Biology of Reproduction | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.