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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/17823
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dc.contributor.authorDe Paula, Ana Claudia B.-
dc.contributor.authorGracioso, Juliano S.-
dc.contributor.authorToma, Walber-
dc.contributor.authorHiruma-Lima, Clélia Akiko-
dc.contributor.authorCarneiro, Everardo M.-
dc.contributor.authorSouza Brito, Alba R. M.-
dc.date.accessioned2014-05-20T13:49:58Z-
dc.date.accessioned2016-10-25T17:02:15Z-
dc.date.available2014-05-20T13:49:58Z-
dc.date.available2016-10-25T17:02:15Z-
dc.date.issued2008-10-01-
dc.identifierhttp://dx.doi.org/10.1016/j.phymed.2008.02.024-
dc.identifier.citationPhytomedicine. Jena: Elsevier Gmbh, Urban & Fischer Verlag, v. 15, n. 10, p. 815-825, 2008.-
dc.identifier.issn0944-7113-
dc.identifier.urihttp://hdl.handle.net/11449/17823-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/17823-
dc.description.abstractThe aim of the present study is to investigate the antiulcerogenic effects of the essential oil (EO) of Croton cajucara Benth in rats fed with a normal protein (NP) and low-protein diet (MN).NP and MN rats were treated with the essential oil for 15 days after chronic ulceration was induced. The EO accelerated healing of acetic acid-induced gastric lesions in NP and MN rats (p < 0.05). In a similar experiment on chronic ulceration, Epidermal Growth Factor (EGF) mRNA expression increased in NP rats but not in MN rats.In assays of acute antiulcerogenic activity, C. cajucara increased somatostatin plasma levels and decreased gastrin plasma levels in both animal groups. The EO significantly prevented ethanol-induced gastric ulcers in NP and MN rats (P < 0.001).Histological examination showed initial regeneration, formation of inflammatory infiltrate and anglogenesis in the epithelium surface of acetic acid-induced ulcers in NP and MN rats. C. cajucara prevented gastric lesions in both animal groups when ethanol methodology was used. We concluded that the EO showed an antiulcerogenic activity mediated by increased somatostatin secretion and EGF mRNA expression. (C) 2008 Elsevier GmbH. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent815-825-
dc.language.isoeng-
dc.publisherElsevier Gmbh, Urban & Fischer Verlag-
dc.sourceWeb of Science-
dc.subjectMalnourished ratsen
dc.subjectEssential oilen
dc.subjectCroton cajucaraen
dc.subjectMedicinal plantsen
dc.subjectGastric ulceren
dc.titleThe antiulcer effect of Croton cajucara Benth in normoproteic and malnourished ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade do Sagrado Coração (USC)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniv Santa Cecilia-
dc.description.affiliationUniv Sagrado Coracao, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Dept Physiol & Biophys, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Inst Biosci, Dept Physiol, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Paulista, Dept Biol Sci, São Paulo, Brazil-
dc.description.affiliationUniv Santa Cecilia, Coll Pharm, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biosci, Dept Physiol, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Dept Biol Sci, São Paulo, Brazil-
dc.identifier.doi10.1016/j.phymed.2008.02.024-
dc.identifier.wosWOS:000260352200005-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPhytomedicine-
dc.identifier.orcid0000-0002-8645-3777pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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