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http://acervodigital.unesp.br/handle/11449/17824
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DC Field | Value | Language |
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dc.contributor.author | Roldao, Erika de Freitas | - |
dc.contributor.author | Witaicenis, Aline | - |
dc.contributor.author | Seito, Leonardo Noboru | - |
dc.contributor.author | Hiruma-Lima, Clélia Akiko | - |
dc.contributor.author | Di Stasi, Luiz Claudio | - |
dc.date.accessioned | 2014-05-20T13:49:58Z | - |
dc.date.accessioned | 2016-10-25T17:02:15Z | - |
dc.date.available | 2014-05-20T13:49:58Z | - |
dc.date.available | 2016-10-25T17:02:15Z | - |
dc.date.issued | 2008-09-02 | - |
dc.identifier | http://dx.doi.org/10.1016/j.jep.2008.06.001 | - |
dc.identifier.citation | Journal of Ethnopharmacology. Clare: Elsevier B.V., v. 119, n. 1, p. 94-98, 2008. | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | http://hdl.handle.net/11449/17824 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/17824 | - |
dc.description.abstract | Ethnopharmacological relevance: Cardia verbenacea is a medicinal plant popularly used in Brazil as antiinflammatory, antiulcer and anti-rheumatic agent without detailed pharmacological and toxicological studies.Aim of the study: The study was aimed to investigate the effects of Cordia verbenacea in antiulcer, analgesic and antioxidant assays, as well as to evaluate its toxic effects and phytochemical profile.Material and methods: Antiulcer activity of plant extract was evaluated using ethanol/HCl, ethanol and piroxican-induced gastric lesions methods. The pH, volume and total acid of gastric juice were determined by pylorus-ligated assay. Analgesic activity was evaluated by writhing, tail-flick and hot-plate tests. Antioxidant activity was determined by in vitro lipoperoxidation assay. Acute toxicity and number of deaths were evaluated by Hippocratic screening.Results: The ethanol leaf extract shows a potent antiulcer activity in the ethanol/HCl and absolute ethanol-induced gastric lesions. The IC50 value of plant extract on the lipid peroxidation was 76.11 mu g/ml. Preliminary phytochemical tests were positive for flavonoids, steroids, saponins, fixed acids, alkaloids and phenols. In the analgesic models the extract did not present any activity.Conclusions: Cordial verbenaceae showed a potent antiulcer activity at the dose of 125 mg/kg and this effect may be associated with an improvement in stomach antioxidant mechanisms. (C) 2008 Elsevier B.V. All rights reserved. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) | - |
dc.format.extent | 94-98 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Cordia verbenacea | en |
dc.subject | Boraginaceae | en |
dc.subject | antiulcer | en |
dc.subject | analgesic | en |
dc.subject | antioxidant | en |
dc.subject | acute toxicity | en |
dc.title | Evaluation of the antiulcerogenic and analgesic activities of Cordia verbenacea DC. (Boraginaceae) | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | São Paulo State Univ UNESP, Inst Biociencias, Dept Pharmacol, Lab Phytomed, BR-1861800 São Paulo, Brazil | - |
dc.description.affiliation | São Paulo State Univ UNESP, Inst Biociencias, Dept Physiol, BR-1861800 São Paulo, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ UNESP, Inst Biociencias, Dept Pharmacol, Lab Phytomed, BR-1861800 São Paulo, Brazil | - |
dc.description.affiliationUnesp | São Paulo State Univ UNESP, Inst Biociencias, Dept Physiol, BR-1861800 São Paulo, Brazil | - |
dc.identifier.doi | 10.1016/j.jep.2008.06.001 | - |
dc.identifier.wos | WOS:000259336600014 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Journal of Ethnopharmacology | - |
dc.identifier.orcid | 0000-0002-8645-3777 | pt |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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