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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/17824
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dc.contributor.authorRoldao, Erika de Freitas-
dc.contributor.authorWitaicenis, Aline-
dc.contributor.authorSeito, Leonardo Noboru-
dc.contributor.authorHiruma-Lima, Clélia Akiko-
dc.contributor.authorDi Stasi, Luiz Claudio-
dc.date.accessioned2014-05-20T13:49:58Z-
dc.date.accessioned2016-10-25T17:02:15Z-
dc.date.available2014-05-20T13:49:58Z-
dc.date.available2016-10-25T17:02:15Z-
dc.date.issued2008-09-02-
dc.identifierhttp://dx.doi.org/10.1016/j.jep.2008.06.001-
dc.identifier.citationJournal of Ethnopharmacology. Clare: Elsevier B.V., v. 119, n. 1, p. 94-98, 2008.-
dc.identifier.issn0378-8741-
dc.identifier.urihttp://hdl.handle.net/11449/17824-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/17824-
dc.description.abstractEthnopharmacological relevance: Cardia verbenacea is a medicinal plant popularly used in Brazil as antiinflammatory, antiulcer and anti-rheumatic agent without detailed pharmacological and toxicological studies.Aim of the study: The study was aimed to investigate the effects of Cordia verbenacea in antiulcer, analgesic and antioxidant assays, as well as to evaluate its toxic effects and phytochemical profile.Material and methods: Antiulcer activity of plant extract was evaluated using ethanol/HCl, ethanol and piroxican-induced gastric lesions methods. The pH, volume and total acid of gastric juice were determined by pylorus-ligated assay. Analgesic activity was evaluated by writhing, tail-flick and hot-plate tests. Antioxidant activity was determined by in vitro lipoperoxidation assay. Acute toxicity and number of deaths were evaluated by Hippocratic screening.Results: The ethanol leaf extract shows a potent antiulcer activity in the ethanol/HCl and absolute ethanol-induced gastric lesions. The IC50 value of plant extract on the lipid peroxidation was 76.11 mu g/ml. Preliminary phytochemical tests were positive for flavonoids, steroids, saponins, fixed acids, alkaloids and phenols. In the analgesic models the extract did not present any activity.Conclusions: Cordial verbenaceae showed a potent antiulcer activity at the dose of 125 mg/kg and this effect may be associated with an improvement in stomach antioxidant mechanisms. (C) 2008 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent94-98-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectCordia verbenaceaen
dc.subjectBoraginaceaeen
dc.subjectantiulceren
dc.subjectanalgesicen
dc.subjectantioxidanten
dc.subjectacute toxicityen
dc.titleEvaluation of the antiulcerogenic and analgesic activities of Cordia verbenacea DC. (Boraginaceae)en
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSão Paulo State Univ UNESP, Inst Biociencias, Dept Pharmacol, Lab Phytomed, BR-1861800 São Paulo, Brazil-
dc.description.affiliationSão Paulo State Univ UNESP, Inst Biociencias, Dept Physiol, BR-1861800 São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Biociencias, Dept Pharmacol, Lab Phytomed, BR-1861800 São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Inst Biociencias, Dept Physiol, BR-1861800 São Paulo, Brazil-
dc.identifier.doi10.1016/j.jep.2008.06.001-
dc.identifier.wosWOS:000259336600014-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofJournal of Ethnopharmacology-
dc.identifier.orcid0000-0002-8645-3777pt
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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