Utilize este identificador para citar ou criar um link para este item:
http://acervodigital.unesp.br/handle/11449/18205
Registro de metadados completo
Campo DC | Valor | Idioma |
---|---|---|
dc.contributor.author | Ehara Watanabe, Maria Angelica | - |
dc.contributor.author | Amarante, Marla Karine | - |
dc.contributor.author | Conti, Bruno Jose | - |
dc.contributor.author | Sforcin, Jose Mauricio | - |
dc.date.accessioned | 2014-05-20T13:51:00Z | - |
dc.date.accessioned | 2016-10-25T17:02:46Z | - |
dc.date.available | 2014-05-20T13:51:00Z | - |
dc.date.available | 2016-10-25T17:02:46Z | - |
dc.date.issued | 2011-11-01 | - |
dc.identifier | http://dx.doi.org/10.1111/j.2042-7158.2011.01331.x | - |
dc.identifier.citation | Journal of Pharmacy and Pharmacology. Malden: Wiley-blackwell, v. 63, n. 11, p. 1378-1386, 2011. | - |
dc.identifier.issn | 0022-3573 | - |
dc.identifier.uri | http://hdl.handle.net/11449/18205 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/18205 | - |
dc.description.abstract | Objectives Propolis is a honeybee product used extensively in traditional medicine for its antioxidant, anti-inflammatory, immunomodulatory and anticancer effects. Propolis exhibits a broad spectrum of biological activities because it is a complex mixture of natural substances. In this review, the antitumour effects of propolis extracts and its constituents (e. g. flavonoids, terpenes and caffeic acid phenethyl ester) are discussed.Key findings The effect of propolis on experimental carcinogenesis is discussed, as well as its possible mechanisms of action against tumours, involving apoptosis, cell cycle arrest and interference on metabolic pathways. Propolis seems to be efficient against different tumour cells both in vitro and in vivo, which suggests its potential in the development of new anticancer drugs.Summary Propolis extracts may be important economically and would allow a relatively inexpensive cancer treatment. Preclinical investigations are needed to further elucidate the benefits of propolis and its antitumour properties. | en |
dc.format.extent | 1378-1386 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-Blackwell | - |
dc.source | Web of Science | - |
dc.subject | caffeic acid phenethyl ester | en |
dc.subject | cancer | en |
dc.subject | diterpenes | en |
dc.subject | flavonoids | en |
dc.subject | propolis | en |
dc.title | Cytotoxic constituents of propolis inducing anticancer effects: a review | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Univ Londrina | - |
dc.description.affiliation | UNESP, Dept Microbiol & Immunol, Biosci Inst, BR-18618970 Botucatu, SP, Brazil | - |
dc.description.affiliation | Univ Londrina, Dept Pathol Sci, Ctr Biol Sci, Londrina, PR, Brazil | - |
dc.description.affiliationUnesp | UNESP, Dept Microbiol & Immunol, Biosci Inst, BR-18618970 Botucatu, SP, Brazil | - |
dc.identifier.doi | 10.1111/j.2042-7158.2011.01331.x | - |
dc.identifier.wos | WOS:000296394200002 | - |
dc.rights.accessRights | Acesso aberto | - |
dc.relation.ispartof | Journal of Pharmacy and Pharmacology | - |
Aparece nas coleções: | Artigos, TCCs, Teses e Dissertações da Unesp |
Não há nenhum arquivo associado com este item.
Itens do Acervo digital da UNESP são protegidos por direitos autorais reservados a menos que seja expresso o contrário.