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DC Field | Value | Language |
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dc.contributor.author | Moreira, Ana Paula | - |
dc.contributor.author | Dias-Melicio, Luciane Alarcao | - |
dc.contributor.author | Victoriano Campos Soares, Angela Maria | - |
dc.date.accessioned | 2014-05-20T13:51:05Z | - |
dc.date.accessioned | 2016-10-25T17:02:49Z | - |
dc.date.available | 2014-05-20T13:51:05Z | - |
dc.date.available | 2016-10-25T17:02:49Z | - |
dc.date.issued | 2010-01-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.cellimm.2010.03.016 | - |
dc.identifier.citation | Cellular Immunology. San Diego: Academic Press Inc. Elsevier B.V., v. 263, n. 2, p. 196-203, 2010. | - |
dc.identifier.issn | 0008-8749 | - |
dc.identifier.uri | http://hdl.handle.net/11449/18241 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/18241 | - |
dc.description.abstract | Paracoccidioidomycosis is caused by the thermally dimorphic fungus Paracoccidioides brasiliensis (P brasiliensis). Most often, this mycosis runs as a chronic progressive course affecting preferentially the lungs. In vitro fungicidal activity against a high virulent strain of P brasiliensis by murine peritoneal macrophages preactivated with IFN-gamma or TNF-alpha is high and correlates with increased NO and H2O2 production. Within this context, the purpose of this work was to study the role of suppressor cytokines, such as IL-10 and TGF-beta, in this process. Incubation of either IFN-gamma or TNF-alpha with IL-10 inhibits fungicidal activity of these cells However, TGF-beta had no effect on fungicidal activity of IFN-gamma or TNF-alpha-activated macrophages. The suppression of fungicidal activity by IL-10 correlated with the inhibition of NO and H2O2 production supporting the involvement of these metabolites in P brasiliensis killing These results suggest that IL-10 production in vivo could represent an evasion mechanism of the fungus to avoid host immune response (C) 2010 Elsevier Inc All rights reserved. | en |
dc.description.sponsorship | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | - |
dc.format.extent | 196-203 | - |
dc.language.iso | eng | - |
dc.publisher | Academic Press Inc. Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | Murine paracoccidioidomycosis | en |
dc.subject | Macrophages | en |
dc.subject | Fungicidal activity | en |
dc.subject | IL-10 | en |
dc.subject | TGF-beta | en |
dc.subject | NO | en |
dc.subject | H2O2 | en |
dc.title | Interleukin-10 but not Transforming Growth Factor beta inhibits murine activated macrophages Paracoccidioides brasiliensis killing: Effect on H2O2 and NO production | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNESP Univ Estadual Paulista, Inst Biociencias, Dept Microbiol & Immunol, BR-18618000 São Paulo, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP Univ Estadual Paulista, Inst Biociencias, Dept Microbiol & Immunol, BR-18618000 São Paulo, SP, Brazil | - |
dc.description.sponsorshipId | FAPESP: 00/04876-8 | - |
dc.identifier.doi | 10.1016/j.cellimm.2010.03.016 | - |
dc.identifier.wos | WOS:000278666800010 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Cellular Immunology | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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