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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/18293
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dc.contributor.authordos Santos, Priscila P.-
dc.contributor.authorNogueira, Bruna F.-
dc.contributor.authorRafacho, Bruna P. M.-
dc.contributor.authorGaiolla, Paula Schmidt Azevedo-
dc.contributor.authorPolegato, Bertha Furlan-
dc.contributor.authorChiuso-Minicucci, Fernanda-
dc.contributor.authorBonomo, Camila-
dc.contributor.authorRoscani, Meliza Goi-
dc.contributor.authorZorzella-Pezavento, Sofia F. G.-
dc.contributor.authorTanni, Suzana E.-
dc.contributor.authorPereira, Elenize J.-
dc.contributor.authorOkoshi, Marina Politi-
dc.contributor.authorPaiva, Sergio Alberto Rupp de-
dc.contributor.authorZornoff, Leonardo Antonio Mamede-
dc.contributor.authorMinicucci, Marcos Ferreira-
dc.date.accessioned2014-05-20T13:51:15Z-
dc.date.available2014-05-20T13:51:15Z-
dc.date.issued2012-01-01-
dc.identifierhttp://dx.doi.org/10.1159/000343309-
dc.identifier.citationCellular Physiology and Biochemistry. Basel: Karger, v. 30, n. 5, p. 1191-1201, 2012.-
dc.identifier.issn1015-8987-
dc.identifier.urihttp://hdl.handle.net/11449/18293-
dc.description.abstractBackground/Aims: Renin-angiotensin-aldosterone system blockade with a mineralocorticoid-receptor antagonist has not yet been studied in exposure to tobacco smoke (TS) models. Thus, this study investigated the role of spironolactone on cardiac remodeling induced by exposure to tobacco smoke. Methods: Male Wistar rats were divided into 4 groups: a control group (group C, n=11); a group with 2 months of cigarette smoke exposure (group TS-C, n=13); a group that received spironolactone 20 mg/kg of diet/day and no cigarette smoke exposure (group TS-S, n=13); and a group with 2 months of cigarette smoke exposure and spironolactone supplementation (group S, n=12). The rats were observed for a period of 60 days, during which morphological, biochemical and functional analyses were performed. Results: There was no difference in invasive mean arterial pressure among the groups. There were no interactions between tobacco smoke exposure and spironolactone in the morphological and functional analysis. However, in the echocardiographic analysis, the TS groups had left chamber enlargement, higher left ventricular mass index and higher isovolumetric relaxation time corrected by heart rate compared with the non-TS groups. In vitro left ventricular diastolic function also worsened in the IS groups and was not influenced by spironolactone. In addition, there were no differences in myocardial levels of IFN-gamma, TNF-alpha, IL-10, ICAM-1 and GLUT4 [TS: OR 0.52, 95%CI (-0.007; 0.11); Spironolactone: OR -0.01, 95%CI (-0.07;0.05)]. Conclusion: Our data do not support the participation of aldosterone in the ventricular remodeling process induced by exposed to cigarette smoke. Copyright (C) 2012 S. Karger AG, Baselen
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent1191-1201-
dc.language.isoeng-
dc.publisherKarger-
dc.sourceWeb of Science-
dc.subjectGLUT4en
dc.subjectInflammationen
dc.subjectVentricular remodelingen
dc.subjectCigarette smokeen
dc.titleAldosterone is not Involved in the Ventricular Remodeling Process Induced by Tobacco Smoke Exposureen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Estadual Paulista UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil-
dc.description.affiliationSão Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Inst Biosci, Dept Microbiol & Immunol, Botucatu, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 10/10187-2-
dc.description.sponsorshipIdCNPq: 473091/2010-0-
dc.identifier.doi10.1159/000343309-
dc.identifier.wosWOS:000312617200009-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000312617200009.pdf-
dc.relation.ispartofCellular Physiology and Biochemistry-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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