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http://acervodigital.unesp.br/handle/11449/18417
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DC Field | Value | Language |
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dc.contributor.author | Mello, MLS | - |
dc.contributor.author | Barbisan, L. F. | - |
dc.contributor.author | Lareef, M. H. | - |
dc.contributor.author | Russo, J. | - |
dc.contributor.author | Vidal, B. D. | - |
dc.date.accessioned | 2014-05-20T13:51:30Z | - |
dc.date.accessioned | 2016-10-25T17:03:02Z | - |
dc.date.available | 2014-05-20T13:51:30Z | - |
dc.date.available | 2016-10-25T17:03:02Z | - |
dc.date.issued | 2004-02-26 | - |
dc.identifier | http://dx.doi.org/10.1016/j.mrfmmm.2003.10.005 | - |
dc.identifier.citation | Mutation Research-fundamental and Molecular Mechanisms of Mutagenesis. Amsterdam: Elsevier B.V., v. 546, n. 1-2, p. 39-43, 2004. | - |
dc.identifier.issn | 0027-5107 | - |
dc.identifier.uri | http://hdl.handle.net/11449/18417 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/18417 | - |
dc.description.abstract | The incidence of apoptosis and nuclear instability, including the incidence of catastrophic death, were investigated in benzo[a]pyrene (BP)-transformed human breast epithelial cells (BP1-E cell line) after microcell-mediated transfer of chromosomes 11 and 17. Since the introduction of normal chromosomes 11 and 17 into tumorigenic human breast BP1-E cells reverts some of these cells' characteristics (especially those affected by microsatellite instabilities and loss of heterozygosity) those of parental non-transformed MCF-10F cells, it was expected that the cell death rates would also be affected by this treatment. The transfer of the mentioned chromosomes, especially chromosome 17, to tumorigenic BP1-E cells increased the apoptotic ratios and decreased the nuclear instability ratios, thus showing that the microsatellite instability and loss of heterozygosity induced by BP in these chromosomes of MCF-10F cells affect the control of cell death mechanisms. (C) 2003 Elsevier B.V. All rights reserved. | en |
dc.format.extent | 39-43 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | apoptosis | pt |
dc.subject | catastrophic death | pt |
dc.subject | human breast epithelial cells | pt |
dc.subject | chromosome 11 | pt |
dc.subject | chromosome 17 | pt |
dc.title | Cell death evaluation in benzo[a]pyrene-transformed human breast epithelial cells after microcell-mediated transfer of chromosomes 11 and 17 | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual de Campinas (UNICAMP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Fox Chase Canc Ctr | - |
dc.description.affiliation | UNICAMP, Inst Biol, Dept Cell Biol, BR-13084971 Campinas, SP, Brazil | - |
dc.description.affiliation | Univ Estadual Paulista Julio Mesquita Filho, Inst Biosci, Dept Morphol, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliation | Fox Chase Canc Ctr, Philadelphia, PA 19111 USA | - |
dc.description.affiliationUnesp | Univ Estadual Paulista Julio Mesquita Filho, Inst Biosci, Dept Morphol, BR-18618000 Botucatu, SP, Brazil | - |
dc.identifier.doi | 10.1016/j.mrfmmm.2003.10.005 | - |
dc.identifier.wos | WOS:000188838800005 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Mutation Research: Fundamental and Molecular Mechanisms of Mutagenesis | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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