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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/18569
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dc.contributor.authorFossato da Silva, Daniela A.-
dc.contributor.authorTeixeira, Carla T.-
dc.contributor.authorScarano, Wellerson R.-
dc.contributor.authorFavareto, Ana Paula A.-
dc.contributor.authorFernandez, Carla D. B.-
dc.contributor.authorGrotto, Denise-
dc.contributor.authorBarbosa, Fernando-
dc.contributor.authorKempinas, Wilma de G.-
dc.date.accessioned2014-05-20T13:51:58Z-
dc.date.accessioned2016-10-25T17:03:13Z-
dc.date.available2014-05-20T13:51:58Z-
dc.date.available2016-10-25T17:03:13Z-
dc.date.issued2011-05-01-
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2011.01.002-
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 31, n. 4, p. 431-439, 2011.-
dc.identifier.issn0890-6238-
dc.identifier.urihttp://hdl.handle.net/11449/18569-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/18569-
dc.description.abstractIn this study we investigated the effects of subacute exposure to methylmercury (MeHg) on male reproductive functions in rats by means of determination of alterations in structural and functional parameters. Adult male Wistar rats received 0, 0.5, 1.0 or 3.0 mg/kg/body weight/day orally, daily MeHg for 14 days. Sperm motility, the relative sperm count and transit time in the caput/corpus epididymis, were all reduced at all doses. The lowest dose increased the number of sperm head abnormalities; daily sperm production was elevated at the intermediate dose; while at the highest dose there was a decrease in serum testosterone levels and a rise in mercury (Hg) content in reproductive organs, liver and kidneys. In conclusion, MeHg exposure produced damages on male reproductive functions which may be attributed, at least in part, to the reduction in serum testosterone levels. These consequences could potentially result in infertility in rats. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.format.extent431-439-
dc.language.isoeng-
dc.publisherPergamon-Elsevier B.V. Ltd-
dc.sourceWeb of Science-
dc.subjectReproductive toxicityen
dc.subjectMethylmercuryen
dc.subjectRaten
dc.subjectTestosteroneen
dc.subjectSpermen
dc.subjectTestisen
dc.subjectEpididymisen
dc.subjectICP-MSen
dc.titleEffects of methylmercury on male reproductive functions in Wistar ratsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Campinas, Inst Biol, Grad Program Cellular & Struct Biol, UNICAMP, Campinas, SP, Brazil-
dc.description.affiliationUniv São Paulo, Dept Clin Toxicol & Bromatol Anal, BR-14049 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUnespUNESP Univ Estadual Paulista, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 07/56458-4-
dc.identifier.doi10.1016/j.reprotox.2011.01.002-
dc.identifier.wosWOS:000291377200008-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofReproductive Toxicology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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