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dc.contributor.authorKuradomi, Rafael Y.-
dc.contributor.authorFigueiredo, Marcio A.-
dc.contributor.authorLanes, Carlos F. C.-
dc.contributor.authorda Rosa, Carlos E.-
dc.contributor.authorAlmeida, Daniela V.-
dc.contributor.authorMaggioni, Rodrigo-
dc.contributor.authorSilva, Maeli D. P.-
dc.contributor.authorMarins, Luis F.-
dc.date.accessioned2014-05-20T13:51:59Z-
dc.date.accessioned2016-10-25T17:03:14Z-
dc.date.available2014-05-20T13:51:59Z-
dc.date.available2016-10-25T17:03:14Z-
dc.date.issued2011-06-01-
dc.identifierhttp://dx.doi.org/10.1007/s11248-010-9429-y-
dc.identifier.citationTransgenic Research. Dordrecht: Springer, v. 20, n. 3, p. 513-521, 2011.-
dc.identifier.issn0962-8819-
dc.identifier.urihttp://hdl.handle.net/11449/18574-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/18574-
dc.description.abstractThe aim of the present study was to analyse the morphology of white skeletal muscle in males and females from the GH-transgenic zebrafish (Danio rerio) lineage F0104, comparing the expression of genes related to the somatotrophic axis and myogenesis. Histological analysis demonstrated that transgenic fish presented enhanced muscle hypertrophy when compared to non-transgenic fish, with transgenic females being more hypertrophic than transgenic males. The expression of genes related to muscle growth revealed that transgenic hypertrophy is independent from local induction of insulin-like growth factor 1 gene (igf1). In addition, transgenic males exhibited significant induction of myogenin gene (myog) expression, indicating that myog may mediate hypertrophic growth in zebrafish males overexpressing GH. Induction of the alpha-actin gene (acta1) in males, independently from transgenesis, also was observed. There were no significant differences in total protein content from the muscle. Our results show that muscle hypertrophy is independent from muscle igf1, and is likely to be a direct effect of excess circulating GH and/or IGF1 in this transgenic zebrafish lineage.en
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.format.extent513-521-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.subjectTransgenic zebrafishen
dc.subjectGrowth hormoneen
dc.subjectSkeletal muscleen
dc.subjectHypertrophyen
dc.subjectMyogenic factorsen
dc.titleGH overexpression causes muscle hypertrophy independent from local IGF-I in a zebrafish transgenic modelen
dc.typeoutro-
dc.contributor.institutionFundação Univ Fed Rio Grande-
dc.contributor.institutionBodo Univ Coll-
dc.contributor.institutionUniversidade Federal do Ceará (UFC)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationFundação Univ Fed Rio Grande, Inst Ciencias Biol, Programa Posgrad Ciencias Fisiol, BR-96201900 Rio Grande, RS, Brazil-
dc.description.affiliationFundação Univ Fed Rio Grande, Inst Oceanog, Programa Posgrad Aquicultura, BR-96201900 Rio Grande, RS, Brazil-
dc.description.affiliationBodo Univ Coll, Fac Biosci & Aquaculture, N-8049 Bodo, Norway-
dc.description.affiliationUniversidade Federal do Ceará (UFC), Inst Ciencias Mar, Fortaleza, Ceara, Brazil-
dc.description.affiliationUNESP, Inst Biociencias, Dept Morfol, Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP, Inst Biociencias, Dept Morfol, Botucatu, SP, Brazil-
dc.identifier.doi10.1007/s11248-010-9429-y-
dc.identifier.wosWOS:000290446200007-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofTransgenic Research-
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