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dc.contributor.authorGuerra, Marina T.-
dc.contributor.authorScarano, Wellerson R.-
dc.contributor.authorde Toledo, Fabiola C.-
dc.contributor.authorFranci, Janete A. A.-
dc.contributor.authorKempinas, Wilma de G.-
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 29, n. 1, p. 99-105, 2010.-
dc.description.abstractPhthalates are environmental contaminants used in the production of plastics, cosmetics and medical devices. Studies on the effects of phthalates on female reproductive health are particularly sparse and mostly restricted to high-dose exposure in rats. In the present study, pregnant rats were treated with 100 mg/kg-d of di-eta-butyl-phthalate (DBP) or only the vehicle (control group), from GD 12 to GD 20 for evaluation of reproductive outcomes and fetal gonads analysis (F0), and from GD 12 to PND 21 to evaluate reproductive development and function on F1 female offspring. Results showed that all parameters were comparable between groups, although there was a significant increase in the fetal weight after DBP exposure. However, the body weight at birth was normal. Based on these data we can conclude that, in these experimental conditions, DBP did not disturb the reproductive development or function of female rats. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.publisherPergamon-Elsevier B.V. Ltd-
dc.sourceWeb of Science-
dc.subjectMaternal exposureen
dc.subjectFemale offspringen
dc.subjectEstrous cycleen
dc.subjectSexual behavioren
dc.titleReproductive development and function of female rats exposed to di-eta-butyl-phthalate (DBP) in utero and during lactationen
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationSão Paulo State Univ, UNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Biol, Grad Program Cell & Struct Biol, São Paulo, Brazil-
dc.description.affiliationUniv São Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, Dept Morphol, Inst Biosci, BR-18618000 Botucatu, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 06/58835-7-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofReproductive Toxicology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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