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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/18596
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dc.contributor.authorPerobelli, Juliana Elaine-
dc.contributor.authorAlves, Thais Regina-
dc.contributor.authorde Toledo, Fabiola Choqueta-
dc.contributor.authorFernandez, Carla Dal Bianco-
dc.contributor.authorAnselmo-Franci, Janete A.-
dc.contributor.authorKlinefelter, Gary R.-
dc.contributor.authorKempinas, Wilma de Grava-
dc.date.accessioned2014-05-20T13:52:03Z-
dc.date.accessioned2016-10-25T17:03:16Z-
dc.date.available2014-05-20T13:52:03Z-
dc.date.available2016-10-25T17:03:16Z-
dc.date.issued2012-06-01-
dc.identifierhttp://dx.doi.org/10.1016/j.reprotox.2011.12.011-
dc.identifier.citationReproductive Toxicology. Oxford: Pergamon-Elsevier B.V. Ltd, v. 33, n. 3, p. 308-315, 2012.-
dc.identifier.issn0890-6238-
dc.identifier.urihttp://hdl.handle.net/11449/18596-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/18596-
dc.description.abstractThis study evaluated the effects of antiandrogen exposure during the prepubertal period on reproductive development and reproductive competence in adults. Male rats were divided into two groups: flutamide, receiving 25 mg/kg/day of flutamide by oral gavage and control, receiving vehicle daily. Dosing continued from PND 21 to 44, and animals were killed on PND 50 or PND 75-80. The epididymis, prostate, vas deferens and seminal vesicle weights were lower in Flutamide group on PND 50, while on PND 80 only seminal vesicle weight was reduced. Fertility assessed by IUI revealed a decrease in the fertility potential in the flutamide-treated adults. Flutamide accelerated sperm transit time through the epididymis, impairing sperm motility and storage. A quantitative analysis of the cauda sperm membrane proteome revealed a few significant changes in protein expression. Thus, exposure to flutamide during the prepubertal period compromises the function of the epididymis along with epididymal sperm quality at adulthood. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent308-315-
dc.language.isoeng-
dc.publisherPergamon-Elsevier B.V. Ltd-
dc.sourceWeb of Science-
dc.subjectAntiandrogenen
dc.subjectRaten
dc.subjectEpididymisen
dc.subjectPrepubertyen
dc.subjectSperm qualityen
dc.subjectFertilityen
dc.subjectProteomicsen
dc.titleImpairment on sperm quality and fertility of adult rats after antiandrogen exposure during prepubertyen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.description.affiliationUniv Estadual Paulista, UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil-
dc.description.affiliationUniv Estadual Campinas, UNICAMP, Inst Biol, Grad Program Cellular & Struct Biol, Campinas, SP, Brazil-
dc.description.affiliationUniv São Paulo, Sch Dent, Dept Morphol Stomatol & Physiol, BR-14049 Ribeirao Preto, SP, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, UNESP, Inst Biosci, Dept Morphol, BR-18618970 Botucatu, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 07/59079-4-
dc.description.sponsorshipIdCNPq: 501339/2010-8-
dc.identifier.doi10.1016/j.reprotox.2011.12.011-
dc.identifier.wosWOS:000303361200006-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofReproductive Toxicology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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