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http://acervodigital.unesp.br/handle/11449/18654
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DC Field | Value | Language |
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dc.contributor.author | Noguti, Juliana | - |
dc.contributor.author | Barbisan, Luis Fernando | - |
dc.contributor.author | Cesar, Augusto | - |
dc.contributor.author | Seabra, Camilo Dias | - |
dc.contributor.author | Choueri, Rodrigo Brasil | - |
dc.contributor.author | Ribeiro, Daniel Araki | - |
dc.date.accessioned | 2014-05-20T13:52:12Z | - |
dc.date.accessioned | 2016-10-25T17:03:21Z | - |
dc.date.available | 2014-05-20T13:52:12Z | - |
dc.date.available | 2016-10-25T17:03:21Z | - |
dc.date.issued | 2012-07-01 | - |
dc.identifier | http://iv.iiarjournals.org/content/26/4/647.abstract | - |
dc.identifier.citation | In Vivo. Athens: Int Inst Anticancer Research, v. 26, n. 4, p. 647-650, 2012. | - |
dc.identifier.issn | 0258-851X | - |
dc.identifier.uri | http://hdl.handle.net/11449/18654 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/18654 | - |
dc.description.abstract | The Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk. | en |
dc.format.extent | 647-650 | - |
dc.language.iso | eng | - |
dc.publisher | Int Inst Anticancer Research | - |
dc.source | Web of Science | - |
dc.subject | Cancer | en |
dc.subject | in vivo models | en |
dc.subject | GST-P 7-7 | en |
dc.subject | review | en |
dc.title | In Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesis | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Federal de São Paulo (UNIFESP) | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | Univ Fed São Paulo, Univ Fed São Paulo, Dept Biosci, São Paulo, SP, Brazil | - |
dc.description.affiliation | Univ Fed São Paulo, Univ Fed São Paulo, Dept Pathol, São Paulo, SP, Brazil | - |
dc.description.affiliation | UNESP, São Paulo State Univ, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, São Paulo State Univ, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil | - |
dc.identifier.wos | WOS:000306397000018 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | In Vivo | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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