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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/18654
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dc.contributor.authorNoguti, Juliana-
dc.contributor.authorBarbisan, Luis Fernando-
dc.contributor.authorCesar, Augusto-
dc.contributor.authorSeabra, Camilo Dias-
dc.contributor.authorChoueri, Rodrigo Brasil-
dc.contributor.authorRibeiro, Daniel Araki-
dc.date.accessioned2014-05-20T13:52:12Z-
dc.date.accessioned2016-10-25T17:03:21Z-
dc.date.available2014-05-20T13:52:12Z-
dc.date.available2016-10-25T17:03:21Z-
dc.date.issued2012-07-01-
dc.identifierhttp://iv.iiarjournals.org/content/26/4/647.abstract-
dc.identifier.citationIn Vivo. Athens: Int Inst Anticancer Research, v. 26, n. 4, p. 647-650, 2012.-
dc.identifier.issn0258-851X-
dc.identifier.urihttp://hdl.handle.net/11449/18654-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/18654-
dc.description.abstractThe Glutatione-S-transferases (GSTs) comprise a family of enzymes closely associated with the cell detoxification of xenobiotics. GSTs exist as homo- or heterodimers and have been grouped into at least seven distinct classes. The main function of GSTs is to catalyze the conjugation of reduced glutathione (GSH) to an electrophilic site of a broad range of potentially toxic and carcinogenic compounds, thereby making such compounds less dangerous and enabling their ready-excretion. Placental GST, known as GST-P 7-7, is the main isoform found in normal placental tissue and comprises 67% of the total GST concentration in this tissue. During development, GST-P 7-7 decreases in concentration and is absent in adult tissues. Interestingly, GST-P 7-7 expression has been detected in adult tissues after exposure to carcinogenic agents in several experimental test systems, being considered a reliable biomarker of exposure and susceptibility in early phases of carcinogenesis. In this article, we review a series of studies involving GST-P 7-7 expression as a suitable tool for understanding cancer pathogenesis, especially cancer risk.en
dc.format.extent647-650-
dc.language.isoeng-
dc.publisherInt Inst Anticancer Research-
dc.sourceWeb of Science-
dc.subjectCanceren
dc.subjectin vivo modelsen
dc.subjectGST-P 7-7en
dc.subjectreviewen
dc.titleIn Vivo Models for Measuring Placental Glutatione-S-transferase (GST-P 7-7) Levels: A Suitable Biomarker for Understanding Cancer Pathogenesisen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Fed São Paulo, Univ Fed São Paulo, Dept Biosci, São Paulo, SP, Brazil-
dc.description.affiliationUniv Fed São Paulo, Univ Fed São Paulo, Dept Pathol, São Paulo, SP, Brazil-
dc.description.affiliationUNESP, São Paulo State Univ, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil-
dc.description.affiliationUnespUNESP, São Paulo State Univ, Dept Morphol, Inst Biosci, Botucatu, SP, Brazil-
dc.identifier.wosWOS:000306397000018-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofIn Vivo-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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