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- Antineoplasic Drug Methotrexate Redox Mechanism Using a Glassy Carbon Electrode
- Univ Coimbra
- Universidade Estadual Paulista (UNESP)
- Hosp Univ Coimbra
- Fundação para a Ciência e a Tecnologia (FCT)
- European Community Fund FEDER
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
- FCT: SFRH/BD/46026/2008
- FCT: SFRH/BPD/36110/2007
- FCT: PTDC/QUI/098562/2008
- FCT: PTDC/SAU-BEB/104643/2008
- European Community Fund FEDER: POCI 2010
- CEMUC-R: 285
- CAPES: 1211-08-0
- Methotrexate (MTX) is an antimetabolite of folic acid indicated in the treatment of a variety of cancers. The electrochemical behaviour of MTX on a glassy carbon electrode was investigated. The MTX oxidation is a complex, pH-dependent, diffusion-controlled irreversible process and proceeds with the transfer of two electrons and two protons and the formation of one electroactive product, 7-hydroxymethotrexate that undergoes a reversible redox reaction. The MTX reduction is a pH-dependent, quasi-reversible process and involves the transfer of two electrons and two protons leading to the formation of an electroactive product.
- Electroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 24, n. 4, p. 917-923, 2012.
- Wiley-v C H Verlag Gmbh
- Glassy carbon
- Acesso restrito
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