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http://acervodigital.unesp.br/handle/11449/19103
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DC Field | Value | Language |
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dc.contributor.author | Pontinha, A. D. R. | - |
dc.contributor.author | Jorge, S. M. A. | - |
dc.contributor.author | Diculescu, V. C. | - |
dc.contributor.author | Vivan, M. | - |
dc.contributor.author | Oliveira-Brett, A. M. | - |
dc.date.accessioned | 2014-05-20T13:53:32Z | - |
dc.date.accessioned | 2016-10-25T17:04:02Z | - |
dc.date.available | 2014-05-20T13:53:32Z | - |
dc.date.available | 2016-10-25T17:04:02Z | - |
dc.date.issued | 2012-04-01 | - |
dc.identifier | http://dx.doi.org/10.1002/elan.201100558 | - |
dc.identifier.citation | Electroanalysis. Weinheim: Wiley-v C H Verlag Gmbh, v. 24, n. 4, p. 917-923, 2012. | - |
dc.identifier.issn | 1040-0397 | - |
dc.identifier.uri | http://hdl.handle.net/11449/19103 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/19103 | - |
dc.description.abstract | Methotrexate (MTX) is an antimetabolite of folic acid indicated in the treatment of a variety of cancers. The electrochemical behaviour of MTX on a glassy carbon electrode was investigated. The MTX oxidation is a complex, pH-dependent, diffusion-controlled irreversible process and proceeds with the transfer of two electrons and two protons and the formation of one electroactive product, 7-hydroxymethotrexate that undergoes a reversible redox reaction. The MTX reduction is a pH-dependent, quasi-reversible process and involves the transfer of two electrons and two protons leading to the formation of an electroactive product. | en |
dc.description.sponsorship | Fundação para a Ciência e a Tecnologia (FCT) | - |
dc.description.sponsorship | European Community Fund FEDER | - |
dc.description.sponsorship | CEMUC-R | - |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | - |
dc.format.extent | 917-923 | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-v C H Verlag Gmbh | - |
dc.source | Web of Science | - |
dc.subject | Glassy carbon | en |
dc.subject | Methotrexate | en |
dc.subject | Oxidation | en |
dc.subject | Reduction | en |
dc.title | Antineoplasic Drug Methotrexate Redox Mechanism Using a Glassy Carbon Electrode | en |
dc.type | outro | - |
dc.contributor.institution | Univ Coimbra | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.contributor.institution | Hosp Univ Coimbra | - |
dc.description.affiliation | Univ Coimbra, Dept Quim, Fac Ciencias & Tecnol, P-3004535 Coimbra, Portugal | - |
dc.description.affiliation | UNESP, Dept Quim & Bioquim, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.affiliation | Hosp Univ Coimbra, P-3000 Coimbra, Portugal | - |
dc.description.affiliationUnesp | UNESP, Dept Quim & Bioquim, Inst Biociencias, BR-18618000 Botucatu, SP, Brazil | - |
dc.description.sponsorshipId | FCT: SFRH/BD/46026/2008 | - |
dc.description.sponsorshipId | FCT: SFRH/BPD/36110/2007 | - |
dc.description.sponsorshipId | FCT: PTDC/QUI/098562/2008 | - |
dc.description.sponsorshipId | FCT: PTDC/SAU-BEB/104643/2008 | - |
dc.description.sponsorshipId | European Community Fund FEDER: POCI 2010 | - |
dc.description.sponsorshipId | CEMUC-R: 285 | - |
dc.description.sponsorshipId | CAPES: 1211-08-0 | - |
dc.identifier.doi | 10.1002/elan.201100558 | - |
dc.identifier.wos | WOS:000302160000026 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Electroanalysis | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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