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Utilize este identificador para citar ou criar um link para este item: http://acervodigital.unesp.br/handle/11449/191
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dc.contributor.authorSilva de Melo, Nathalie Ferreira-
dc.contributor.authorGrillo, Renato-
dc.contributor.authorGuilherme, Viviane Aparecida-
dc.contributor.authorde Araujo, Daniele Ribeiro-
dc.contributor.authorde Paula, Eneida-
dc.contributor.authorRosa, Andre Henrique-
dc.contributor.authorFraceto, Leonardo Fernandes-
dc.date.accessioned2014-05-20T13:12:12Z-
dc.date.accessioned2016-10-25T16:32:34Z-
dc.date.available2014-05-20T13:12:12Z-
dc.date.available2016-10-25T16:32:34Z-
dc.date.issued2011-08-01-
dc.identifierhttp://dx.doi.org/10.1007/s11095-011-0425-6-
dc.identifier.citationPharmaceutical Research. New York: Springer/plenum Publishers, v. 28, n. 8, p. 1984-1994, 2011.-
dc.identifier.issn0724-8741-
dc.identifier.urihttp://hdl.handle.net/11449/191-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/191-
dc.description.abstractThe aim of this work was to investigate the influence of the oily nucleus composition on physico-chemical properties and anesthetic activity of poly (lactide-co-glycolide) nanocapsules with benzocaine.Nanocapsules containing benzocaine were prepared with three different oily nucleus composition and characterized by mean diameter, polydispersivity, zeta potential, pH and stability were investigated as a function of time. In vitro release kinetics were performed in a system with two compartments separated by a cellulose membrane. Intensity and duration of analgesia were evaluated in rats by sciatic nerve blockade.The greatest stability, slower release profile and improvement in the local anesthetic activity of BZC were obtained with the formulation using USP mineral oil as component.Results from our study provide useful perspectives on selection of the primary materials needed to produce suspensions of polymeric nanocapsules able to act as carriers of BZC, with potential future application in the treatment of pain.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipFundação para o Desenvolvimento da UNESP (FUNDUNESP)-
dc.format.extent1984-1994-
dc.language.isoeng-
dc.publisherSpringer/plenum Publishers-
dc.sourceWeb of Science-
dc.subjectbenzocaineen
dc.subjectlocal anestheticen
dc.subjectnanocapsuleen
dc.subjectoily nucleusen
dc.subjectPLGAen
dc.titlePoly(Lactide-co-Glycolide) Nanocapsules Containing Benzocaine: Influence of the Composition of the Oily Nucleus on Physico-Chemical Properties and Anesthetic Activityen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Federal do ABC (UFABC)-
dc.description.affiliationSão Paulo State Univ UNESP, Dept Environm Engn, BR-18087180 Sorocaba, SP, Brazil-
dc.description.affiliationState Univ Campinas UNICAMP, Dept Biochem, BR-13083970 Campinas, SP, Brazil-
dc.description.affiliationFed Univ ABC UFABC, Human & Nat Sci Ctr, BR-09210170 Santo Andre, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Environm Engn, BR-18087180 Sorocaba, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 06-00121-9-
dc.description.sponsorshipIdFAPESP: 07/00127-0-
dc.identifier.doi10.1007/s11095-011-0425-6-
dc.identifier.wosWOS:000292518800017-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPharmaceutical Research-
dc.identifier.orcid0000-0002-2042-018Xpt
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