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DC Field | Value | Language |
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dc.contributor.author | Mendes, M. A. | - |
dc.contributor.author | de Souza, B. M. | - |
dc.contributor.author | Marques, M. R. | - |
dc.contributor.author | Palma, Mario Sergio | - |
dc.date.accessioned | 2014-05-20T13:54:43Z | - |
dc.date.accessioned | 2016-10-25T17:04:44Z | - |
dc.date.available | 2014-05-20T13:54:43Z | - |
dc.date.available | 2016-10-25T17:04:44Z | - |
dc.date.issued | 2004-07-01 | - |
dc.identifier | http://dx.doi.org/10.1016/j.toxicon.2004.04.009 | - |
dc.identifier.citation | Toxicon. Oxford: Pergamon-Elsevier B.V., v. 44, n. 1, p. 67-74, 2004. | - |
dc.identifier.issn | 0041-0101 | - |
dc.identifier.uri | http://hdl.handle.net/11449/19601 | - |
dc.identifier.uri | http://acervodigital.unesp.br/handle/11449/19601 | - |
dc.description.abstract | The venom of the neotropical social wasp Agelaia pallipes pallipes was fractionated by RP-HPLC resulting in the elution of seven fractions; the last two were re-fractionated under RP-HPLC by using isocratic elution conditions and the purity of the fractions were confirmed by using ESI-MS analysis. Both fractions are constituted of peptide components, which were sequenced by Edman degradation chemistry, resulting in the following sequences:Protonectin I-L-G-T-I-L-G-L-L-K-G-L-NH2Agelaia-MP I-N-W-L-K-L-G-K-A-I-I-D-A-L-NH2Both peptides are manually synthesized on solid-phase and functionally characterized by using Wistar rats cells. Protonectin is a non-hemolytic chemotactic peptide for polymorphonucleated leukocytes (PMNL), presenting some mast cell degranulating activity and potent antimicrobial action both against Gram-positive and Gram-negative bacteria. Agelaia-MP was characterized as a hemolytic mast cell degranulator toxin, presenting a poor antimicrobial action and no chemotaxis for PMNL. (C) 2004 Elsevier Ltd. All rights reserved. | en |
dc.format.extent | 67-74 | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier B.V. | - |
dc.source | Web of Science | - |
dc.subject | social wasp | pt |
dc.subject | chemotactic peptide | pt |
dc.subject | mastoparan | pt |
dc.subject | hemolysis | pt |
dc.subject | antimicrobial peptide | pt |
dc.title | Structural and biological characterization of two novel peptides from the venom of the neotropical social wasp Agelaia pallipes pallipes | en |
dc.type | outro | - |
dc.contributor.institution | Universidade Estadual Paulista (UNESP) | - |
dc.description.affiliation | UNESP, CEIS Dept Biol, IBRC, CAT,CEPID,FAPESP,Inst Immunol Invest,Millennium I, BR-12506900 Rio Claro, SP, Brazil | - |
dc.description.affiliationUnesp | UNESP, CEIS Dept Biol, IBRC, CAT,CEPID,FAPESP,Inst Immunol Invest,Millennium I, BR-12506900 Rio Claro, SP, Brazil | - |
dc.identifier.doi | 10.1016/j.toxicon.2004.04.009 | - |
dc.identifier.wos | WOS:000222714400008 | - |
dc.rights.accessRights | Acesso restrito | - |
dc.relation.ispartof | Toxicon | - |
Appears in Collections: | Artigos, TCCs, Teses e Dissertações da Unesp |
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