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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/19637
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dc.contributor.authorMalini, Maressa-
dc.contributor.authorMarin-Morales, Maria Aparecida-
dc.contributor.authorMantovani, Mário Sérgio-
dc.contributor.authorJamal, Claudia Masrouah-
dc.contributor.authorNati, Natália-
dc.contributor.authorPassos, Tatiane da Silva-
dc.contributor.authorMatsumoto, Silvia Tamie-
dc.date.accessioned2014-05-20T13:54:50Z-
dc.date.available2014-05-20T13:54:50Z-
dc.date.issued2010-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572009005000106-
dc.identifier.citationGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 33, n. 1, p. 176-181, 2010.-
dc.identifier.issn1415-4757-
dc.identifier.urihttp://hdl.handle.net/11449/19637-
dc.description.abstractAn aqueous extract of Rhizophora mangle L. bark is used as raw material in pottery making in the State of Espirito Santo, Brazil. This extract presents large quantities of tannins, compounds possessing antioxidant properties. Tannin antioxidant activity, as a plant chemical defense mechanism in the process of stabilizing free radicals, has been an incentive to studies on anti-mutagenicity. The present work aimed to evaluate possible antimutagenic activity of a R. mangle aqueous extract, using the Allium cepa test-system and micronuclear (MN) assay with blockage of cytokinesis in Chinese hamster ovary cells (CHO-K1). The Allium cepa test-system indicated antimutagenic activity against the damage induced by the mutagenic agent methyl methanesulfonate. A reduction in both MN cell frequency and chromosome breaks occurred in both the pre and post-treatment protocols. The MN testing of CHO-K1 cells revealed anti-mutagenic activity of the R. mangle extract against methyl methanesulfonate and doxorubicin in pre, simultaneous and post-treatment protocols. These results suggest the presence of phyto-constituents in the extract presenting demutagenic and bio-antimutagenic activities. Since the chemical constitution of Rhizophora mangle species presents elevated tannin content, it is highly probable that these compounds are the antimutagenic promoters themselves.en
dc.format.extent176-181-
dc.language.isoeng-
dc.publisherSociedade Brasileira de Genética-
dc.sourceSciELO-
dc.subjectRhizophora mangleen
dc.subjectantimutagenicityen
dc.subjectAllium cepaen
dc.subjectCHO-K1en
dc.titleDetermination of the antimutagenicity of an aqueous extract of Rhizophora mangle L. (Rhizophoraceae), using in vivo and in vitro test systemsen
dc.typeoutro-
dc.contributor.institutionUniversidade Federal do Espírito Santo (UFES)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Londrina (UEL)-
dc.description.affiliationUniversidade Federal do Espírito Santo (UFES) Departamento de Ciências Biológicas-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Biologia-
dc.description.affiliationUniversidade Estadual de Londrina (UEL) Departamento de Genética-
dc.description.affiliationUniversidade Federal do Espírito Santo (UFES) Departamento de Ciências Farmacêuticas-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Biologia-
dc.identifier.doi10.1590/S1415-47572009005000106-
dc.identifier.scieloS1415-47572010000100029-
dc.identifier.wosWOS:000275106000029-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS1415-47572010000100029.pdf-
dc.relation.ispartofGenetics and Molecular Biology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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