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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/19670
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dc.contributor.authorGomes, Paulo C.-
dc.contributor.authorde Souza, Bibiana M.-
dc.contributor.authorDias, Nathalia B.-
dc.contributor.authorCesar-Tognoli, Lilian M. M.-
dc.contributor.authorSilva-Filho, Luiz C.-
dc.contributor.authorTormena, Claudio F.-
dc.contributor.authorRittner, Roberto-
dc.contributor.authorRichardson, Michael-
dc.contributor.authorCordeiro, Marta N.-
dc.contributor.authorPalma, Mario Sergio-
dc.date.accessioned2014-05-20T13:54:59Z-
dc.date.available2014-05-20T13:54:59Z-
dc.date.issued2011-02-01-
dc.identifierhttp://dx.doi.org/10.1016/j.toxicon.2010.11.021-
dc.identifier.citationToxicon. Oxford: Pergamon-Elsevier B.V. Ltd, v. 57, n. 2, p. 266-274, 2011.-
dc.identifier.issn0041-0101-
dc.identifier.urihttp://hdl.handle.net/11449/19670-
dc.description.abstractNigriventrine was isolated from the armed spider Phoneutria nigriventer, in which it constitutes about 0.4% of the total venom content. Its structure was determined to be [1,1`-(1-hydroxyhydrazine-1,2-diyl)bis(oxy)bis(4-hydroxy-2,6-dioxopiperidine-4 carboxylic acid)] by NMR, HR-ES/IMS and MS/MS methods. The intracerebroventricular application of nigriventrine in rat brain, followed by the detection of c-Fos protein expression, indicated that the compound was neuroactive in the motor cortex, sensory cortex, piriform cortex, median preoptic nucleus, dorsal endopiriform nucleus, lateral septal nucleus and hippocampus of rat brain. Nigriventrine causes convulsions in rats, even when peripherally applied. (c) 2010 Elsevier Ltd. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.description.sponsorshipINCT-Imunologia-
dc.format.extent266-274-
dc.language.isoeng-
dc.publisherPergamon-Elsevier B.V. Ltd-
dc.sourceWeb of Science-
dc.subjectSpider venomen
dc.subjectSpectroscopyen
dc.subjectLow molecular massen
dc.subjectNeurotoxinen
dc.subjectGlutamate receptoren
dc.subjectNatural producten
dc.titleNigriventrine: A low molecular mass neuroactive compound from the venom of the spider Phoneutria nigriventeren
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionFundação Ezequiel Dias (FUNED)-
dc.description.affiliationSão Paulo State Univ UNESP, Dept Biol CEIS, Inst Biosci, São Paulo, Brazil-
dc.description.affiliationSão Paulo State Univ UNESP, Dept Chem, Fac Sci, São Paulo, Brazil-
dc.description.affiliationUniv Estadual Campinas, Inst Chem, São Paulo, Brazil-
dc.description.affiliationEzequiel Dias Fdn FUNED, Ctr Res & Dev, Belo Horizonte, MG, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Biol CEIS, Inst Biosci, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ UNESP, Dept Chem, Fac Sci, São Paulo, Brazil-
dc.description.sponsorshipIdFAPESP: 04/07942-2-
dc.description.sponsorshipIdFAPESP: 06/57122-6-
dc.description.sponsorshipIdCNPq: 472870/2004-1-
dc.identifier.doi10.1016/j.toxicon.2010.11.021-
dc.identifier.wosWOS:000287629400010-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000287629400010.pdf-
dc.relation.ispartofToxicon-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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