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Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/19701
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dc.contributor.authorde Souza, Bibiana Monson-
dc.contributor.authorRodrigues da Silva, Alessandra Vaso-
dc.contributor.authorFerreira Resende, Virginia Maria-
dc.contributor.authorArcuri, Helen Andrade-
dc.contributor.authordos Santos Cabrera, Marcia Perez-
dc.contributor.authorRuggiero Neto, Joao-
dc.contributor.authorPalma, Mario Sergio-
dc.date.accessioned2014-05-20T13:55:05Z-
dc.date.accessioned2016-10-25T17:04:55Z-
dc.date.available2014-05-20T13:55:05Z-
dc.date.available2016-10-25T17:04:55Z-
dc.date.issued2009-08-01-
dc.identifierhttp://dx.doi.org/10.1016/j.peptides.2009.05.008-
dc.identifier.citationPeptides. New York: Elsevier B.V., v. 30, n. 8, p. 1387-1395, 2009.-
dc.identifier.issn0196-9781-
dc.identifier.urihttp://hdl.handle.net/11449/19701-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/19701-
dc.description.abstractHymenoptera venoms are complex mixtures of biochemically and pharmacologically active components such as biogenic amines, peptides and proteins. Polycationic peptides generally constitute the largest group of Hymenoptera venom toxins, and the mastoparans constitute the most abundant and important class of peptides in the venom of social wasps. These toxins are responsible for histamine release from mast cells, serotonin from platelets, and catecholamines and adenylic acids from adrenal chromafin cells. The present work reports the structural and functional characterization of two novel mastoparan peptides identified from the venom of the neotropical social wasp Polybia paulista. The mastoparans Polybia-MP-II and -III were purified, sequenced and synthesized on solid phase using Fmoc chemistry and the synthetic peptides used for structural and functional characterizations. Polybia-MP-II and -III are tetradecapeptides, amidated at their C-termini, and form amphipathic alpha-helical conformations under membrane-mimetic conditions. Both peptides were polyfunctional, causing pronounced cell lysis of rat mast cells and erythrocytes, in addition to having antimicrobial activity against both Gram-positive and Gram-negative bacteria. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent1387-1395-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectWasp venomen
dc.subjectToxinsen
dc.subjectMastoparanen
dc.subjectPeptide-membrane interactionen
dc.subjectCell lysisen
dc.titleCharacterization of two novel polyfunctional mastoparan peptides from the venom of the social wasp Polybia paulistaen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSão Paulo State Univ, UNESP, CEIS, IBRC,Dept Biol, BR-13506900 Rio Claro, SP, Brazil-
dc.description.affiliationUNESP, IBILCE, Dept Phys, Sao Jose do Rio Preto, SP, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, UNESP, CEIS, IBRC,Dept Biol, BR-13506900 Rio Claro, SP, Brazil-
dc.description.affiliationUnespUNESP, IBILCE, Dept Phys, Sao Jose do Rio Preto, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 04/07942-2-
dc.description.sponsorshipIdFAPESP: 06/57122-6-
dc.identifier.doi10.1016/j.peptides.2009.05.008-
dc.identifier.wosWOS:000269038200001-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofPeptides-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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