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dc.contributor.authorKobayashi, Claudia A. N.-
dc.contributor.authorLeite, Aline L.-
dc.contributor.authorSilva, Thelma L.-
dc.contributor.authorSantos, Lucilene D.-
dc.contributor.authorNogueira, Fabio C. S.-
dc.contributor.authorOliveiraa, Rodrigo C.-
dc.contributor.authorPalma, Mario Sergio-
dc.contributor.authorDomont, Gilberto B.-
dc.contributor.authorBuzalaf, Marilia A. R.-
dc.date.accessioned2014-05-20T13:56:01Z-
dc.date.accessioned2016-10-25T17:05:30Z-
dc.date.available2014-05-20T13:56:01Z-
dc.date.available2016-10-25T17:05:30Z-
dc.date.issued2009-07-15-
dc.identifierhttp://dx.doi.org/10.1016/j.cbi.2009.03.009-
dc.identifier.citationChemico-biological Interactions. Clare: Elsevier B.V., v. 180, n. 2, p. 305-311, 2009.-
dc.identifier.issn0009-2797-
dc.identifier.urihttp://hdl.handle.net/11449/20035-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/20035-
dc.description.abstractTwo-dimensional gel electrophoresis (2-DE) was used to better understand alterations in renal metabolism induced by fluoride (F). Three groups of weanling male Wistar rats were treated with drinking water containing 0 (control), 5, or 50 ppm F for 60 days (n=6/group). Kidneys were collected for proteomic and histological (HE) analysis. After protein isolation, renal proteome profiles were examined using 2-DE and Colloidal Coomassie Blue staining. Protein spots with a 2-fold significant difference as detected by quantitative intensity analysis (image Master Platinum software) and t-test (p < 0.05) were excised and analyzed by MALDI-TOF MS (matrix assisted laser desorption ionization-time-of-flight mass spectrometry). The histological analysis revealed no damage in kidneys induced by F, except for a vascular congestion in the 50 ppm F group. Between control vs 50 ppm F, and control vs 5 ppm F groups, 12 and 6 differentially expressed proteins were detected, respectively. Six proteins, mainly related with metabolism, detoxification and housekeeping, were successfully identified. At the high F group, pyruvate carboxylase, a protein involved in the formation of oxaloacetate was found to be downregulated, while enoyl coenzyme A hydratase, involved in fatty acids oxidation, was found to be upregulated. Thus, proteomic analysis can provide new insights into the alterations in renal metabolism after F exposure, even in low doses. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent305-311-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectProteomicsen
dc.subjectMass spectrometryen
dc.subjectTwo-dimensional gel electrophoresisen
dc.subjectFluorideen
dc.subjectKidneyen
dc.subjectMetabolismen
dc.titleProteomic analysis of kidney in rats chronically exposed to fluorideen
dc.typeoutro-
dc.contributor.institutionUniversidade de São Paulo (USP)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal do Rio de Janeiro (UFRJ)-
dc.description.affiliationUniv São Paulo, Bauru Dent Sch, Bauru, SP, Brazil-
dc.description.affiliationUniv Estadual Paulista, Rio Claro Biosci Inst, Rio Claro, SP, Brazil-
dc.description.affiliationUniv Fed Rio de Janeiro, Inst Chem, Rio de Janeiro, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Rio Claro Biosci Inst, Rio Claro, SP, Brazil-
dc.description.sponsorshipIdFAPESP: 05/02744-0-
dc.description.sponsorshipIdFAPESP: 05/03273-1-
dc.description.sponsorshipIdCNPq: 307006/2006-9-
dc.identifier.doi10.1016/j.cbi.2009.03.009-
dc.identifier.wosWOS:000267584000021-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofChemico-biological Interactions-
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