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dc.contributor.authorLedesma Contarteze, Ricardo Vinicius-
dc.contributor.authorde Alencar Mota, Clecia Soares-
dc.contributor.authorMachado de Oliveira, Camila Aparecida-
dc.contributor.authorCuriacos de Almeida Leme, Jose Alexandre-
dc.contributor.authorBottcher, Lara Belmudes-
dc.contributor.authorRostom de Mello, Maria Alice-
dc.contributor.authorLuciano, Eliete-
dc.identifier.citationJournal of Diabetes. Hoboken: Wiley-blackwell, v. 1, n. 1, p. 65-72, 2009.-
dc.description.abstractBackground: Animal models appear well-suited for studies into the role of exercise in the prevention of non-insulin-dependent diabetes mellitus (NIDDM). The aim of the present study was to analyze glucose homeostasis and blood lactate during an exercise swimming test in rats treated with alloxan during the neonatal period and/or fed a high calorie diet from weaning onwards.Methods: Rats were injected with alloxan (200 mg/kg, i.p.) or vehicle (citrate buffer) at 6 days of age. After weaning, rats were divided into four groups and fed either a balanced diet or a high-caloric diet as follows: C, control group (vehicle + normal diet); A, alloxan-treated rats fed the normal diet; H, vehicle-treated rats fed the high-caloric diet; and HA, alloxan-treated rats fed the high-caloric diet.Results: Fasting serum glucose levels were higher in groups A and AH compared with the control group. The Homeostatic Model Assessment index varied in the groups as follows: H > A > HA = C. There were no differences in free fatty acids or blood lactate concentrations during the swim test.Conclusions: Alloxan-treated rats fed a normal or high-caloric diet have the potential to be used in studies analyzing the role physical exercise plays in the prevention of NIDDM.en
dc.sourceWeb of Science-
dc.titleExercise test and glucose homeostasis in rats treated with alloxan during the neonatal period or fed a high calorie dieten
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationSão Paulo State Univ, Dept Phys Educ, São Paulo, Brazil-
dc.description.affiliationUnespSão Paulo State Univ, Dept Phys Educ, São Paulo, Brazil-
dc.rights.accessRightsAcesso aberto-
dc.relation.ispartofJournal of Diabetes-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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