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dc.contributor.authorMachado de Oliveira, Camila Aparecida-
dc.contributor.authorLatorraca, Marcia Queiroz-
dc.contributor.authorRostom de Mello, Maria Alice-
dc.contributor.authorCarneiro, Everardo Magalhaes-
dc.date.accessioned2013-09-30T18:49:05Z-
dc.date.accessioned2014-05-20T13:58:40Z-
dc.date.accessioned2016-10-25T17:07:05Z-
dc.date.available2013-09-30T18:49:05Z-
dc.date.available2014-05-20T13:58:40Z-
dc.date.available2016-10-25T17:07:05Z-
dc.date.issued2011-04-01-
dc.identifierhttp://dx.doi.org/10.1007/s00726-010-0716-y-
dc.identifier.citationAmino Acids. New York: Springer, v. 40, n. 4, p. 1027-1034, 2011.-
dc.identifier.issn0939-4451-
dc.identifier.urihttp://hdl.handle.net/11449/20843-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/20843-
dc.description.abstractProtein restriction at early stages of life reduces beta-cell volume, number of insulin-containing granules, insulin content and release by pancreatic islets in response to glucose and other secretagogues, abnormalities similar to those seen in type 2 diabetes. Amino acids are capable to directly modulate insulin secretion and/or contribute to the maintenance of beta-cell function, resulting in an improvement of insulin release. Animal models of protein malnutrition have provided important insights into the adaptive mechanisms involved in insulin secretion in malnutrition. In this review, we discuss studies focusing on the modulation of insulin secretion by amino acids, specially leucine and taurine, in rodent models of protein malnutrition. Leucine supplementation increases insulin secretion by pancreatic islets in malnourished mice. This effect is at least in part due to increase in the expression of proteins involved in the secretion process, and the activation of the PI3K/PKB/mTOR pathway seems also to contribute. Mice supplemented with taurine have increased insulin content and secretion as well as increased expression of genes essential for beta-cell functionality. The knowledge of the mechanisms through which amino acids act on pancreatic beta-cells to stimulate insulin secretion is of interest for clinical medicine. It can reveal new targets for the development of drugs toward the treatment of endocrine diseases, in special type 2 diabetes.en
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)-
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de Mato Grosso (FAPEMAT)-
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)-
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)-
dc.format.extent1027-1034-
dc.language.isoeng-
dc.publisherSpringer-
dc.sourceWeb of Science-
dc.subjectMalnutritionen
dc.subjectInsulin secretionen
dc.subjectAmino acidsen
dc.subjectLeucineen
dc.subjectTaurineen
dc.titleMechanisms of insulin secretion in malnutrition: modulation by amino acids in rodent modelsen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)-
dc.contributor.institutionUniversidade Federal de Mato Grosso (UFMT)-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)-
dc.description.affiliationUniv Estadual Campinas UNICAMP, Dept Anat Biol Celular Fisiol & Biofis, São Paulo, Brazil-
dc.description.affiliationUniv Fed Mato Grosso UFMT, Dept Alimentos & Nutr, Fac Nutr, Cuiaba, Mato Grosso, Brazil-
dc.description.affiliationUniv Estadual Paulista UNESP, Dept Educ Fis, São Paulo, Brazil-
dc.description.affiliationUniv Fed São Paulo Unifesp, Dept Biociencias, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista UNESP, Dept Educ Fis, São Paulo, Brazil-
dc.identifier.doi10.1007/s00726-010-0716-y-
dc.identifier.wosWOS:000288546700002-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofAmino Acids-
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