You are in the accessibility menu

Please use this identifier to cite or link to this item: http://acervodigital.unesp.br/handle/11449/21268
Full metadata record
DC FieldValueLanguage
dc.contributor.authorKristensen, Karina-
dc.contributor.authorBerenbrink, Michael-
dc.contributor.authorKoldkjaer, Pia-
dc.contributor.authorAbe, Augusto Shinya-
dc.contributor.authorWang, Tobias-
dc.date.accessioned2014-05-20T14:00:08Z-
dc.date.accessioned2016-10-25T17:07:49Z-
dc.date.available2014-05-20T14:00:08Z-
dc.date.available2016-10-25T17:07:49Z-
dc.date.issued2008-05-01-
dc.identifierhttp://dx.doi.org/10.1016/j.cbpa.2008.03.002-
dc.identifier.citationComparative Biochemistry and Physiology A-molecular & Integrative Physiology. New York: Elsevier B.V., v. 150, n. 1, p. 46-51, 2008.-
dc.identifier.issn1095-6433-
dc.identifier.urihttp://hdl.handle.net/11449/21268-
dc.identifier.urihttp://acervodigital.unesp.br/handle/11449/21268-
dc.description.abstractRed blood cells (RBCs) from most vertebrates restore volume upon hypertonic shrinkage and the mechanisms underlying this regulatory volume increase (RVI) have been studied extensively in these cells. Despite the phylogenetically interesting position of reptiles, very little is known about their red cell function. The present study demonstrates that oxygenated RBCs in all major groups of reptiles exhibit no or a very reduced RVI upon -25% calculated hyperosmotic shrinkage. Thus, RBCs from the snakes Crotalus durissus and Python regius, the turtle Trachemys scripta and the alligator Alligator mississippiensis showed no statistically significant RVI within 120 min after shrinkage, while the lizard Tupinambis merianae showed 22% volume recovery after 120 min. Amiloride (10(-4) M) and bumetanide (10(-5) M) had no effect on the RVI in T merianae, indicating no involvement of the Na(+)/H(+) exchanger (NHE) or the Na(+)/K(+)/2Cl(-) co-transporter (NKCC) or insentive transporters. Deoxygenation of RBCs from A. mississippiensis and T merianae did not significantly affect RVI upon shrinkage. Deoxygenation per se of red blood cells from T merianae elicited a slow volume increase, but the mechanism was not characterized. It seems, therefore, that the RVI response based on NHE activation was lost among the early sauropsids that gave rise to modern reptiles and birds, while it was retained in mammals. An RVI response has then reappeared in birds, but based on activation of the NKCC. Alternatively, the absence of the RVI response may represent the most ancient condition, and could have evolved several times within vertebrates. (C) 2008 Elsevier B.V. All rights reserved.en
dc.format.extent46-51-
dc.language.isoeng-
dc.publisherElsevier B.V.-
dc.sourceWeb of Science-
dc.subjectred blood cellsen
dc.subjectvolume regulationen
dc.subjectregulatory volume increaseen
dc.subjectNa plus /H plus exchangeren
dc.subjectNa+/K+/2Cl-co-transporteren
dc.subjectreptileen
dc.titleMinimal volume regulation after shrinkage of red blood cells from five species of reptilesen
dc.typeoutro-
dc.contributor.institutionUniv Aarhus-
dc.contributor.institutionUniv Liverpool-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Aarhus, Dept Biol Sci, DK-8000 Aarhus C, Denmark-
dc.description.affiliationUniv Liverpool, Sch Biol Sci, Liverpool L69 3BX, Merseyside, England-
dc.description.affiliationUNESP, Dept Zool, Rio Claro, SP, Brazil-
dc.description.affiliationUnespUNESP, Dept Zool, Rio Claro, SP, Brazil-
dc.identifier.doi10.1016/j.cbpa.2008.03.002-
dc.identifier.wosWOS:000256499700008-
dc.rights.accessRightsAcesso restrito-
dc.relation.ispartofComparative Biochemistry and Physiology A-molecular & Integrative Physiology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

There are no files associated with this item.
 

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.