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dc.contributor.authorCaviedes-Vidal, Enrique-
dc.contributor.authorKarasov, William H.-
dc.contributor.authorChediack, Juan Gabriel-
dc.contributor.authorFasulo, Veronica-
dc.contributor.authorCruz-Neto, Ariovaldo P.-
dc.contributor.authorOtani, Lye-
dc.date.accessioned2014-05-20T14:00:15Z-
dc.date.available2014-05-20T14:00:15Z-
dc.date.issued2008-01-09-
dc.identifierhttp://dx.doi.org/10.1371/journal.pone.0001425-
dc.identifier.citationPlos One. San Francisco: Public Library Science, v. 3, n. 1, p. 8, 2008.-
dc.identifier.issn1932-6203-
dc.identifier.urihttp://hdl.handle.net/11449/21313-
dc.description.abstractBats tend to have less intestinal tissue than comparably sized nonflying mammals. The corresponding reduction in intestinal volume and hence mass of digesta carried is advantageous because the costs of flight increase with load carried and because take-off and maneuverability are diminished at heavier masses. Water soluble compounds, such as glucose and amino acids, are absorbed in the small intestine mainly via two pathways, the transporter-mediated transcellular and the passive, paracellular pathways. Using the microchiropteran bat Artibeus literatus (mean mass 80.6 +/- 3.7 g), we tested the predictions that absorption of water-soluble compounds that are not actively transported would be extensive as a compensatory mechanism for relatively less intestinal tissue, and would decline with increasing molecular mass in accord with sieve-like paracellular absorption. Using a standard pharmacokinetic technique, we fed, or injected intraperitonealy the metabolically inert carbohydrates L-rhamnose (molecular mass = 164 Da) and cellobiose (molecular mass = 342 Da) which are absorbed only by paracellular transport, and 3-O-methyl-D-glucose (3OMD-glucose) which is absorbed via both mediated (active) and paracellular transport. As predicted, the bioavailability of paracellular probes declined with increasing molecular mass (rhamnose, 90 +/- 11%; cellobiose, 10 +/- 3%, n = 8) and was significantly higher in bats than has been reported for laboratory rats and other mammals. In addition, absorption of 3OMD-glucose was high (96 +/- 11%). We estimated that the bats rely on passive, paracellular absorption for more than 70% of their total glucose absorption, much more than in non-flying mammals. Although possibly compensating for less intestinal tissue, a high intestinal permeability that permits passive absorption might be less selective than a carrier-mediated system for nutrient absorption and might permit toxins to be absorbed from plant and animal material in the intestinal lumen.en
dc.description.sponsorshipNational Science Foundation (NSF) - USA-
dc.description.sponsorshipAgencia Nacional de Promoción Científica y Tecnológica (ANPCYT)-
dc.description.sponsorshipUniversidad Nacional de San Luis (Argentina)-
dc.description.sponsorshipMax McGraw Wildlife Foundation-
dc.format.extent8-
dc.language.isoeng-
dc.publisherPublic Library Science-
dc.sourceWeb of Science-
dc.titleParacellular Absorption: A Bat Breaks the Mammal Paradigmen
dc.typeoutro-
dc.contributor.institutionUniv Nacl San Luis-
dc.contributor.institutionUniv Wisconsin Madison-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.description.affiliationUniv Nacl San Luis, CONICET, Fac Ciencias Humanas, Lab Biol Prof E Caviedes Codelia, San Luis, Argentina-
dc.description.affiliationUniv Nacl San Luis, Dept Bioquim & Ciencias Biol, San Luis, Argentina-
dc.description.affiliationUniv Wisconsin Madison, Dept Wildlife Ecol, Madison, WI USA-
dc.description.affiliationUniv Nacl San Luis, Fac Ciencias Human, Area Psicobiol, San Luis, Argentina-
dc.description.affiliationUniv Estadual Paulista, Inst Biocien, Dept Zool, São Paulo, Brazil-
dc.description.affiliationUnespUniv Estadual Paulista, Inst Biocien, Dept Zool, São Paulo, Brazil-
dc.description.sponsorshipIdNSF: IBN-0216709-
dc.description.sponsorshipIdNSF(USA): IOS-0615678-
dc.description.sponsorshipIdUNSL (Argentina): 25561-
dc.description.sponsorshipIdUniversidad Nacional de San Luis (Argentina): 22Q751-
dc.identifier.doi10.1371/journal.pone.0001425-
dc.identifier.wosWOS:000260469400021-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileWOS000260469400021.pdf-
dc.relation.ispartofPLOS ONE-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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