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dc.contributor.authorBellini, Marilanda Ferreira-
dc.contributor.authorSilva, Ana Elizabete-
dc.contributor.authorVarella-Garcia, Marileila-
dc.date.accessioned2014-05-20T14:00:40Z-
dc.date.available2014-05-20T14:00:40Z-
dc.date.issued2010-01-01-
dc.identifierhttp://dx.doi.org/10.1590/S1415-47572010005000028-
dc.identifier.citationGenetics and Molecular Biology. Sociedade Brasileira de Genética, v. 33, n. 2, p. 205-213, 2010.-
dc.identifier.issn1415-4757-
dc.identifier.urihttp://hdl.handle.net/11449/21443-
dc.description.abstractThis review summarizes the chromosomal changes detected by molecular cytogenetic approaches in esophageal squamous cell carcinoma (ESCC), the ninth most common malignancy in the world. Whole genome analyses of ESCC cell lines and tumors indicated that the most frequent genomic gains occurred at 1, 2q, 3q, 5p, 6p, 7, 8q, 9q, 11q, 12p, 14q, 15q, 16, 17, 18p, 19q, 20q, 22q and X, with focal amplifications at 1q32, 2p16-22, 3q25-28, 5p13-15.3, 7p12-22, 7q21-22, 8q23-24.2, 9q34, 10q21, 11p11.2, 11q13, 13q32, 14q13-14, 14q21, 14q31-32, 15q22-26, 17p11.2, 18p11.2-11.3 and 20p11.2. Recurrent losses involved 3p, 4, 5q, 6q, 7q, 8p, 9, 10p, 12p, 13, 14p, 15p, 18, 19p, 20, 22, Xp and Y. Gains at 5p and 7q, and deletions at 4p, 9p, and 11q were significant prognostic factors for patients with ESCC. Gains at 6p and 20p, and losses at 10p and 10q were the most significant imbalances, both in primary carcinoma and in metastases, which suggested that these regions may harbor oncogenes and tumor suppressor genes. Gains at 12p and losses at 3p may be associated with poor relapse-free survival. The clinical applicability of these changes as markers for the diagnosis and prognosis of ESCC, or as molecular targets for personalized therapy should be evaluated.en
dc.format.extent205-213-
dc.language.isoeng-
dc.publisherSociedade Brasileira de Genética-
dc.sourceSciELO-
dc.subjectCGHen
dc.subjectesophageal carcinomaen
dc.subjectFishen
dc.subjectGenomic imbalancesen
dc.subjectMolecular cytogeneticen
dc.titleGenomic imbalances in esophageal squamous cell carcinoma identified by molecular cytogenetic techniquesen
dc.typeoutro-
dc.contributor.institutionUniversidade Estadual Paulista (UNESP)-
dc.contributor.institutionUniversity of Colorado-
dc.description.affiliationUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Biologia Laboratório de Citogenética e Biologia Molecular-
dc.description.affiliationUniversity of Colorado Medicine/Medical Oncology, Health Sciences Center-
dc.description.affiliationUnespUniversidade Estadual Paulista Júlio de Mesquita Filho Departamento de Biologia Laboratório de Citogenética e Biologia Molecular-
dc.identifier.doi10.1590/S1415-47572010005000028-
dc.identifier.scieloS1415-47572010000200001-
dc.identifier.wosWOS:000278958700001-
dc.rights.accessRightsAcesso aberto-
dc.identifier.fileS1415-47572010000200001.pdf-
dc.relation.ispartofGenetics and Molecular Biology-
Appears in Collections:Artigos, TCCs, Teses e Dissertações da Unesp

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